PGE2 promotes renal carcinoma cell invasion through activated RalA.

Oncogene
Z LiYehia Daaka

Abstract

Incidence of kidney cancer is on the rise, and a better understanding of molecular mechanisms involved in the cancer invasion and metastasis is required for the development of curative therapeutics. In this study, we report that the proinflammatory cytokine prostaglandin E2 (PGE2) induces the malignant SN12C, but not benign HK2 kidney cell invasion. The PGE2 increases SN12C cell invasion through a signal pathway that encompasses EP2 and EP4, Akt, small GTPase RalA and Ral·GTP inactivator RGC2. The results support the idea that targeted interference of EP2/EP4 signal to RalA·GTP may provide benefit to patients diagnosed with advanced kidney cancer.

References

Apr 21, 1999·Current Opinion in Cell Biology·L M LuttrellR J Lefkowitz
Mar 30, 2001·The Journal of Biological Chemistry·H ShengR N DuBois
Jun 26, 2003·The Journal of Biological Chemistry·F Gregory BuchananRaymond N DuBois
Nov 11, 2003·Journal of Biochemistry·Masakazu Hattori, Nagahiro Minato
Jun 19, 2004·Current Opinion in Urology·Masaru Murai, Mototsugu Oya
Nov 19, 2005·Science·Maria Domenica CastelloneJ Silvio Gutkind
Mar 29, 2006·The Journal of Experimental Medicine·Dingzhi WangRaymond N DuBois
May 16, 2006·Urology·Andrew N YoungMahul B Amin
Nov 8, 2006·Molecular Cancer Therapeutics·Ogechi N IkediobiRichard Wooster
Dec 19, 2006·Current Biology : CB·Kian-Huat LimChristopher M Counter
Jan 12, 2007·The New England Journal of Medicine·Robert J MotzerRobert A Figlin
Mar 3, 2007·The Journal of Biological Chemistry·Yukihiko Sugimoto, Shuh Narumiya
Aug 22, 2007·Molecular and Cellular Biology·JuanJuan YinKathleen Kelly
Nov 9, 2007·Annual Review of Physiology·Chuan-Ming Hao, Matthew D Breyer
Jan 26, 2008·Nature Reviews. Cancer·Brian O Bodemann, Michael A White
Sep 12, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne Schlesinger-RaabJutta Engel
Dec 30, 2008·Urologic Oncology·Steven Christopher Smith, Dan Theodorescu
Jun 24, 2009·Nature Reviews. Clinical Oncology·Swethajit Biswas, Tim Eisen
Feb 20, 2010·Nature Reviews. Cancer·Dingzhi Wang, Raymond N Dubois
Mar 5, 2010·Clinical Pharmacology and Therapeutics·F Balkwill, A Mantovani
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 29, 2010·Cancer Research·Rachelle L Dillon, William J Muller
May 12, 2010·Nature Reviews. Urology·Maxine SunPierre I Karakiewicz
May 18, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Paul Dorian
Dec 15, 2010·Molecular Biology of the Cell·Xiao-Wei ChenAlan R Saltiel
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 9, 2011·Circulation Research·Scott M DeWire, Jonathan D Violin

❮ Previous
Next ❯

Citations

Jun 30, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rania NasrallahRichard L Hébert
Jul 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shengli ZhangZengjun Wang
Jan 6, 2015·Acta Pharmacologica Sinica·Sunny Guin, Dan Theodorescu
Jun 19, 2013·Pharmacological Reviews·Utako YokoyamaYoshihiro Ishikawa
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Debashree BasudharDavid A Wink
Aug 24, 2018·Cancer Metastasis Reviews·Megan L SulcinerDipak Panigrahy
Nov 23, 2019·Cancer Science·Kohei OsawaYoshihiro Ishikawa
Apr 4, 2014·Cancer Prevention Research·James R Goodman, Douglas Grossman

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
light microscopy
pull down
GTPases
PCR
gene knockdown
pull-down

Software Mentioned

Adobe Illustrator
GraphPad Prism
ImageJ
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.