PMID: 6965522Feb 14, 1980Paper

PGE2 stimulates gastric chloride transport: possible key to cytoprotection

Nature
R SchiesselW Silen

Abstract

Prostaglandins protect the stomach against a variety of noxious agents independently of effects on acid secretion, but the mechanism of this 'cytoprotection' is unknown. We recently proposed that gastric surface cells extrude or eliminate luminal acid by a process analogous to that described in squid axon, snail neurone, and barnacle muscle. Influxing luminal H+ combines with HCO3- which has entered the cell in exchange for intracellular chloride, probably at the nutrient membrane. Dehydration of the resulting H2CO3 into CO2 and H2O is catalysed by carbonic anhydrase, which is present in surface cells in large amounts. Interference with this chain of reactions at any point frequently causes ulceration. We have examined the effect of 16,16-dimethylprostaglandin E2 (PGE) on different segments of this protective mechanism and show here that the protective effects are intimately associated with stimulation of chloride transport. All experiments were done in vitro thus eliminating any effects of prostaglandin on mucosal circulation.

References

Jan 1, 1969·The American Journal of Physiology·J G Forte
Jan 1, 1948·The Biochemical Journal·R E Davies, N M Longmuir

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Citations

Dec 1, 1980·Digestive Diseases and Sciences·D Rachmilewitz
Feb 1, 1986·Digestive Diseases and Sciences·F E SilversteinD S Levine
Oct 1, 1983·Digestive Diseases and Sciences·J N HuntL Kessler
Mar 1, 1981·World Journal of Surgery·F G MoodyK R Larsen
Mar 1, 1981·World Journal of Surgery·W SilenJ N Simson
Mar 1, 1981·World Journal of Surgery·D Fromm
Jan 1, 1981·Prostaglandins·A Robert
Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·T J Sernka, T L Means
Dec 1, 1984·Gut·D S Rampton, C J Hawkey
Dec 25, 1980·Nature·R P Durbin
May 1, 1984·International Journal of Radiation Oncology, Biology, Physics·D GalM D Mitchell
Feb 22, 1988·The American Journal of Medicine·C J Shorrock, W D Rees
Oct 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L R Empey, R N Fedorak
Jul 1, 1982·Arthritis and Rheumatism·R B Zurier
Jun 1, 1985·The Journal of Pediatrics·B L SilvermanC E Hunt
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler
Jun 1, 1981·Pharmacological Research Communications·T CerianiU Ventura

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