PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth.

Prostaglandins & Other Lipid Mediators
Artiom GruzdevBeverly H Koller

Abstract

The ductus arteriosus (DA) is a fetal shunt that directs right ventricular outflow away from pulmonary circulation and into the aorta. Critical roles for prostaglandin E(2) (PGE(2)) and the EP4 receptor (EP4) have been established in maintaining both the patency of the vessel in utero and in its closure at birth. Here we have generated mice in which loss of EP4 expression is limited to either the smooth muscle (SMC) or endothelial cells and demonstrated that SMC, but not endothelial cell expression of EP4 is required for DA closure. The genome wide expression analysis of full term wild type and EP4(-/-) DA indicates that PGE(2)/EP4 signaling modulates expression of a number of unique pathways, including those involved in SMC proliferation, cell migration, and vascular tone. Together this supports a mechanism by which maturation and increased contractility of the vessel is coupled to the potent smooth muscle dilatory actions of PGE(2).

References

Jan 18, 1975·Lancet·R B ElliottJ M Neutze
Sep 2, 1976·The New England Journal of Medicine·M A HeymannN H Silverman
Dec 1, 1992·The Journal of Clinical Investigation·J F EngelhardtJ M Wilson
Mar 1, 1973·Canadian Journal of Physiology and Pharmacology·F Coceani, P M Olley
Jan 1, 1994·Canadian Journal of Physiology and Pharmacology·F CoceaniE Seidlitz
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Jun 19, 1998·Journal of Theoretical Biology·N G Smith
Jun 8, 1999·The Journal of Clinical Investigation·S L TilleyB H Koller
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C A MasonM Rabinovitch
Jan 29, 2000·The Journal of Veterinary Medical Science·T TakizawaA Kamata
Jun 15, 2000·Nature Cell Biology·I MoranoM Bader
Jul 27, 2000·Journal of Cellular Physiology·J A CarvajalC P Weiner
Dec 6, 2000·Genesis : the Journal of Genetics and Development·F W FarleyS M Dymecki
Feb 22, 2001·Biochemical and Biophysical Research Communications·Y YamanakaK Sobue
Jul 4, 2001·The Journal of Clinical Investigation·S Narumiya, G A FitzGerald
Feb 13, 2002·Molecular and Cellular Biology·Birgit AndréeThomas Brand
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rita HoltwickMichaela Kuhn
Jun 11, 2002·British Journal of Pharmacology·Takayuki FujinoFumitaka Ushikubi
Mar 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen L TilleyBeverly H Koller
Dec 31, 2003·Circulation Research·Marit J BootAdriana C Gittenberger-de Groot
Oct 12, 2004·FEBS Letters·Jason R TuckermanDavid R Mole
Dec 22, 2004·The Journal of Biological Chemistry·Bose S KochupurakkalYosef Yarden
Dec 19, 2007·Journal of Molecular and Cellular Cardiology·Thiago T MacielAlexandre H Campos

❮ Previous
Next ❯

Citations

Aug 1, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Utako Yokoyama
Aug 13, 2015·The Journal of Pediatrics·Nahid WalehRonald I Clyman
Mar 22, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yi-Ting HsiehSusumu Minamisawa
Apr 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael PuppoloSusan A Jansen
Jul 29, 2016·Experimental Biology and Medicine·Pratik ParikhDavid A Dean
Feb 16, 2019·Journal of the American Heart Association·Marcela HerreraThomas M Coffman
May 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Oliver PohlJean-Pierre Gotteland
May 3, 2014·Physiological Genomics·Elaine L SheltonJeff Reese
Jun 19, 2013·Pharmacological Reviews·Utako YokoyamaYoshihiro Ishikawa
Jul 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Christopher W HooperElaine L Shelton
Apr 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Taro HiromiYoshihiro Ishikawa
Feb 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Igor V KizubSachin A Gupte
Aug 6, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael T YarboroJeff Reese

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.