PMID: 1707Apr 2, 1975

pH and bicarbonate excretion in the rat parotid gland as a function of salivary rate

Pflügers Archiv : European journal of physiology
H M SommerE Drack


The bicarbonate concentration in rat parotid saliva increases with increasing flow rates and approximates plasma values at highest salivation. At lowest flow rates the bicarbonate concentration in the secretory fluid markedly exceeds the plasma levels. Intravenous administration of acetazolamide has no influence on the bicarbonate excretion of the parotid gland. Following retrograde application of acetazolamide into the gland duct the concentrations of both bicarbonate and sodium are elevated. The potassium concentrations in final saliva exceed 70 mEq/l at flow rates below 5 mul/min g gland weight. With increasing flow rates a precipitous decrease in potassium concentration below 10 mEq/l occurs. With further increase in flow rate the potassium concentration remains unchanged. The sodium concentrations increased with augmented salivation rate. At lowest flow rates the sodium concentrations showed an increase of modest degree. Our findings can best be explained by the existence of two independent ductular mechanism: a) bicarbonate reabsorption probably in the striated ducts of the parotid gland; b) secretion of potassium with concomitand secretion of bicarbonate in the main excretory duct.


Jul 1, 1972·Physiological Reviews·L H SchneyerC A Schneyer
Nov 1, 1972·European Journal of Clinical Investigation·W KreusserH Knauf
Jul 1, 1973·The American Journal of Physiology·J A MangosK Irwin
Aug 1, 1973·The American Journal of Physiology·J A MangosR Hong
May 24, 1974·Pflügers Archiv : European journal of physiology·D KaiserE Drack
Oct 1, 1967·Physiological Reviews·T H Maren
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A Young, E Schögel
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A MangosK F Hamann
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J R MartinezA Frick
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A Mangos, G Braun
Jan 1, 1967·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A YoungK F Hamann
Jan 1, 1970·Pflügers Archiv : European journal of physiology·H Knauf, E Frömter
Jan 1, 1968·Pflügers Archiv : European journal of physiology·E UhlichK J Ullrich
Jul 1, 1954·The American Journal of Physiology·J H THAYSENI L SCHWARTZ
Sep 1, 1961·The Journal of Clinical Investigation·D G JOHNSA S BURGEN
Jan 1, 1962·The American Journal of Physiology·S W BRUSILOW, C L DIAZ


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Jan 1, 1980·Annals of the New York Academy of Sciences·J A YoungI Novak
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Related Concepts

Acetazolamide Sodium, (Sterile)
Carbonic Acid Ions
Hydrogen-Ion Concentration
Parotid Gland
Secretion of Saliva

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