PMID: 1707Apr 2, 1975

pH and bicarbonate excretion in the rat parotid gland as a function of salivary rate

Pflügers Archiv : European journal of physiology
H M SommerE Drack

Abstract

The bicarbonate concentration in rat parotid saliva increases with increasing flow rates and approximates plasma values at highest salivation. At lowest flow rates the bicarbonate concentration in the secretory fluid markedly exceeds the plasma levels. Intravenous administration of acetazolamide has no influence on the bicarbonate excretion of the parotid gland. Following retrograde application of acetazolamide into the gland duct the concentrations of both bicarbonate and sodium are elevated. The potassium concentrations in final saliva exceed 70 mEq/l at flow rates below 5 mul/min g gland weight. With increasing flow rates a precipitous decrease in potassium concentration below 10 mEq/l occurs. With further increase in flow rate the potassium concentration remains unchanged. The sodium concentrations increased with augmented salivation rate. At lowest flow rates the sodium concentrations showed an increase of modest degree. Our findings can best be explained by the existence of two independent ductular mechanism: a) bicarbonate reabsorption probably in the striated ducts of the parotid gland; b) secretion of potassium with concomitand secretion of bicarbonate in the main excretory duct.

References

Jul 1, 1972·Physiological Reviews·L H SchneyerC A Schneyer
Nov 1, 1972·European Journal of Clinical Investigation·W KreusserH Knauf
Jul 1, 1973·The American Journal of Physiology·J A MangosK Irwin
Aug 1, 1973·The American Journal of Physiology·J A MangosR Hong
May 24, 1974·Pflügers Archiv : European journal of physiology·D KaiserE Drack
Oct 1, 1967·Physiological Reviews·T H Maren
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A Young, E Schögel
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A MangosK F Hamann
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J R MartinezA Frick
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A Mangos, G Braun
Jan 1, 1967·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J A YoungK F Hamann
Jan 1, 1970·Pflügers Archiv : European journal of physiology·H Knauf, E Frömter
Jan 1, 1968·Pflügers Archiv : European journal of physiology·E UhlichK J Ullrich
Jul 1, 1954·The American Journal of Physiology·J H THAYSENI L SCHWARTZ
Sep 1, 1961·The Journal of Clinical Investigation·D G JOHNSA S BURGEN
Jan 1, 1962·The American Journal of Physiology·S W BRUSILOW, C L DIAZ

Citations

Dec 2, 2010·Cell and Tissue Research·Eleni Roussa
Aug 10, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jordan Ned SmithCharles Timchalk
Dec 23, 2009·The Journal of Physiology·Marcelo A CatalánJ E Melvin
Jan 1, 1991·Archives of Oral Biology·F J DowdM Makoid
Jan 1, 1980·Annals of the New York Academy of Sciences·J A YoungI Novak
Jun 20, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jingchao LiKyungpyo Park
Jan 1, 1991·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A M Beal

Related Concepts

Acetazolamide Sodium, (Sterile)
Metazoa
Carbonic Acid Ions
Hydrogen-Ion Concentration
Parotid Gland
Salagen
Potassium
Saliva
Secretion of Saliva
Sodium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.