pH-Assisted control over the binding and relocation of an acridine guest between a macrocyclic nanocarrier and natural DNA

Physical Chemistry Chemical Physics : PCCP
Mhejabeen Sayed, Haridas Pal

Abstract

The differential binding affinity of the hydroxypropyl-β-cyclodextrin (HPβCD) macrocycle, a drug delivery vehicle, towards the protonated and deprotonated forms of the well-known DNA binder and model anticancer drug acridine has been exploited as a strategy for dye-drug transportation and pH-responsive delivery to a natural DNA target. From pH-sensitive changes in the ground state absorption and steady-state fluorescence characteristics of the studied acridine dye-HPβCD-DNA ternary system and strongly supported by fluorescence lifetime, fluorescence anisotropy, Job's plots, (1)H NMR and circular dichroism results, it is revealed that in a moderately alkaline solution (pH ∼ 8.5), the dye can be predominantly bound to the HPβCD macrocycle and when the pH is lowered to a moderately acidic region (pH ∼ 4), the dye efficiently detaches from the HPβCD cavity and almost exclusively binds to DNA. In the present study we are thus able to construct a pH-sensitive supramolecular assembly where pH acts as a simple stimulus for controlled uptake and targeted release of the dye-drug. As pH is an essential and sensitive factor in various biological processes, a simple yet reliable pH-sensitive model such as is demonstrated here can have promi...Continue Reading

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Citations

Jan 14, 2016·Physical Chemistry Chemical Physics : PCCP·Pronab KunduNitin Chattopadhyay
Nov 4, 2016·The Journal of Physical Chemistry. B·Shrikant S ThakareNagayan Sekar
Jan 13, 2017·Chemical Communications : Chem Comm·Mai KishimotoMichito Yoshizawa
Nov 26, 2016·Biosensors & Bioelectronics·Benoit ChovelonCorinne Ravelet
Aug 23, 2016·Physical Chemistry Chemical Physics : PCCP·Mhejabeen SayedHaridas Pal
Aug 26, 2017·Physical Chemistry Chemical Physics : PCCP·Mhejabeen SayedHaridas Pal
May 27, 2020·Chemistry : a European Journal·Cristina ParisiSalvatore Sortino
Jun 27, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Arjun SharmaManoj Kumbhakar
Oct 29, 2020·Physical Chemistry Chemical Physics : PCCP·Sharmistha Dutta Choudhury, Haridas Pal
Nov 18, 2021·Physical Chemistry Chemical Physics : PCCP·Mhejabeen Sayed, Haridas Pal

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