PMID: 39188May 1, 1979

pH-Dependence of water and solute transport in toad urinary bladder

Kidney International
C P CarvounisR M Hays

Abstract

Stimulation of urea and water transport by vasopressin (ADH) appears to occur via independent pathways. We examined the effects of altering serosal or mucosal bath pH on transport of water, urea, and sodium. Compared to bladders with a serosal bath pH of 7.4 to 8.0, reducing the serosal bath pH to 6.8 led to a 60% fall in ADH-stimulated osmotic water flow, without decreasing the permeability of urea. Raising the serosal pH to 9.5 had the opposite effect: urea permeability was inhibited by 40% without altering water flow. Exogenous cyclic AMP-stimulated water and urea permeabilities were not dissociated, but were changed in the same direction by alterations in serosal pH: serosal acidification enhanced the effect of exogenous cyclic AMP on both urea and water, whereas the cyclic AMP effect on both was diminished by serosal alkalinization. This was especially marked for urea, suggesting that an alteration in the urea response to cyclic AMP may be particularly important in defining vasopressin-stimulated urea permeability as the serosal bath pH is altered. Mucosal acidification increased short circuit current but decreased both the urea and water response to ADH and 8-bromo-cyclic AMP. The response to cyclic AMP was less consisten...Continue Reading

References

Nov 1, 1969·The Journal of Clinical Investigation·P F Gulyassy
Jan 1, 1972·Pflügers Archiv : European journal of physiology·R N KhuriA Kalloghlian
Jun 1, 1973·The Journal of Clinical Investigation·S D LevineR M Hays
Jan 1, 1963·The Journal of General Physiology·A Essig, A Leaf
Dec 1, 1970·The Journal of Membrane Biology·R M Hays, N Franki

Citations

Jan 1, 1980·Pflügers Archiv : European journal of physiology·M ParisiL Alvarez
Oct 1, 1984·Pflügers Archiv : European journal of physiology·M Parisi, J Wietzerbin
Dec 1, 2007·Journal of Biological Physics·Mario ParisiRoxana Toriano
May 8, 1995·Biochimica Et Biophysica Acta·V LyallT U Biber
Nov 1, 1988·Clinical and Experimental Pharmacology & Physiology·W Fitzgibbon, T Morgan
Aug 1, 1985·The Journal of Clinical Investigation·C P CarvounisB J Wilk
Jan 1, 1990·The Journal of Clinical Investigation·I D Weiner, L L Hamm
Jan 1, 1984·The Journal of Membrane Biology·W A Kachadorian, J Muller
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Hyo-Jung ChoiTae-Hwan Kwon

Related Concepts

Cyclic AMP, (R)-Isomer
Salientia
Urinary Bladder
Hydrogen-Ion Concentration
Tissue Membrane
Sodium
Carmol
Pitressin

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