pH-Dependent aggregation properties of mixtures of sugar-based gemini surfactants with phospholipids and single-tailed surfactants

Langmuir : the ACS Journal of Surfaces and Colloids
Marco ScarzelloJan B F N Engberts

Abstract

Sugar-based gemini surfactants (GSs) display rich pH-dependent phase diagrams and are considered to be promising candidates as gene- and drug-delivery vehicles for biomedical applications. Several sugar-based GSs form vesicles around neutral pH. The vesicular dispersions undergo transitions toward wormlike micelles and spherical micelles at acidic pH, whereas flocculation followed by redispersion upon charge reversal is observed at basic pH. The influence of various amounts of the double-tailed phospholipids DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) and DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and of the single-tailed surfactants lyso-PC (1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine) and OTAC (octadecyltrimethylammonium chloride) on the phase behavior of GS1 (1,8-bis(N-octadec-9-yl-1-deoxy-D-glucitol-1-ylamino)3,6-dioxaoctane) was determined as a function of pH, in water and in water at physiological ionic strength. The pH corresponding to the phase transitions and the characteristics of the aggregates were determined by means of a combination of physical techniques: static and dynamic light scattering (SLS and DLS), fluorescence spectroscopy, cryo-TEM and diffusion- and (31)P NMR. The results show that t...Continue Reading

References

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Citations

Jul 17, 2010·Analytical and Bioanalytical Chemistry·D R GaugerW Pohle
Dec 21, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Yutaka TakahashiPieter Stroeve
May 29, 2014·Chemical Communications : Chem Comm·Na DuRenjie Zhang
Jun 9, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Luc WasunguDick Hoekstra
Sep 23, 2006·Organic & Biomolecular Chemistry·Jaap E KlijnJan B F N Engberts
Sep 13, 2012·The Journal of Physical Chemistry. B·Jagannath MondalArun Yethiraj
Aug 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Christophe B MinkenbergJan H van Esch
Jun 29, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Songbai LiuHua Wang
Nov 23, 2007·Journal of Colloid and Interface Science·Kenichi SakaiMasahiko Abe
Oct 10, 2008·Advances in Colloid and Interface Science·Kieran Trickett, Julian Eastoe
Jan 28, 2014·Journal of Colloid and Interface Science·Haifeng ShiJacques L Zakin
Jan 8, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Anja RankRolf Schubert
Jan 12, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Gunjan VermaEric W Kaler
Sep 16, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaoyu ZhuRenjie Zhang
Feb 17, 2015·The Journal of Physical Chemistry. B·Ruiying SongWanguo Hou
Nov 30, 2007·The Journal of Physical Chemistry. B·Na DuShu-E Song
Oct 27, 2006·The Journal of Physical Chemistry. B·Jaap E KlijnJan B F N Engberts

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