pH-dependent nanodiamonds enhance the mechanical properties of 3D-printed hyaluronic acid nanocomposite hydrogels.

Journal of Nanobiotechnology
Dae Gon LimSeong Hoon Jeong

Abstract

Nanocomposite hydrogels capable of undergoing manufacturing process have recently attracted attention in biomedical applications due to their desired mechanical properties and high functionality. 3D printing nanocomposite hydrogels of hyaluronic acid (HA)/nanodiamond (ND) revealed that the addition of ND with the low weight ratio of 0.02 wt% resulted in higher compressive force and gel breaking point, compared with HA only nanocomposites. These HA nanocomposite hydrogels loaded with surface functionalized ND allowed for the enforced compressive stress to be tuned in a pH-dependent manner. HA nanocomposite hydrogels with ND-OH at pH 8 showed an increase of 1.40-fold (0.02%: 236.18 kPa) and 1.37-fold (0.04%: 616.72 kPa) the compressive stress at the composition of 0.02 wt% and 0.04 wt, respectively, compared to those of ND-COOH (0.02%: 168.31 kPa, 0.04%: 449.59 kPa) at the same pH. Moreover, the compressive stress of HA/ND-OH (0.04 wt%) at pH 8 was mechanically enhanced 1.29-fold, compared to that of HA/ND-OH (0.04 wt%) at pH 7. These results indicate that the tunable buffering environment and interaction with the long chains of HA at the molecular level have a critical role in the dependency of the mechanical properties on pH. D...Continue Reading

References

Jan 11, 2005·Biomacromolecules·Jason A BurdickRobert Langer
Aug 24, 2010·Advanced Materials·Aleksander SkardalGlenn D Prestwich
Mar 12, 2011·Advanced Materials·Jason A Burdick, Glenn D Prestwich
Dec 20, 2011·Nature Nanotechnology·Vadym N MochalinYury Gogotsi
May 9, 2014·Nature Communications·Maling GouShaochen Chen
Apr 18, 2015·Advanced Materials·James O HardinJennifer A Lewis
Jul 17, 2015·Advanced Materials·Christopher B HighleyJason A Burdick
Oct 17, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Wei ZhuLijie Grace Zhang
May 20, 2016·Pharmaceutical Research·Mohamed A AlhnanBasel Arafat
Aug 23, 2016·ACS Applied Materials & Interfaces·Dae Gon LimSeong Hoon Jeong
Oct 22, 2016·Advanced Healthcare Materials·Jia Min Lee, Wai Yee Yeong
Nov 20, 2016·International Journal of Pharmaceutics·Dae Gon LimSeong Hoon Jeong
Dec 13, 2016·ACS Applied Materials & Interfaces·Min-Chul KimEunah Kang
Sep 7, 2017·ACS Applied Materials & Interfaces·Napolabel B PalaganasRigoberto C Advincula
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Dong-Keun LeeDean Ho
Nov 9, 2017·ACS Applied Materials & Interfaces·Sijun LiuLin Li
Nov 23, 2017·ACS Applied Materials & Interfaces·Seon Sook LeeByeongmoon Jeong
Mar 2, 2018·ACS Applied Materials & Interfaces·Yifei JinYong Huang
Jul 13, 2018·Pharmaceutical Research·Witold JamrózRenata Jachowicz
Aug 14, 2019·ACS Applied Materials & Interfaces·Cheng-Tien Hsieh, Shan-Hui Hsu
Oct 10, 2019·ACS Applied Materials & Interfaces·Bowen Yang, Weizhong Yuan
Oct 11, 2019·Advanced Materials·David ChimeneAkhilesh K Gaharwar
Oct 29, 2019·ACS Applied Materials & Interfaces·Asghar ShiraniDiana Berman
Jan 8, 2020·ACS Applied Materials & Interfaces·Felipe Olate-MoyaHumberto Palza
Oct 10, 2016·ACS Biomaterials Science & Engineering·Liliang OuyangJason A Burdick

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scanning electron microscopy
force measurement

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