PMID: 7081980Apr 1, 1982Paper

pH-dependent penicillin tolerance may protect intraleukocytic Staphylococcus aureus from killing by cloxacillin

Antimicrobial Agents and Chemotherapy
N Craven, J C Anderson


Exposure of Staphylococcus aureus to cloxacillin at neutral pH rendered the bacteria more susceptible to subsequent lysis by lysostaphin. This sensitization effect also occurred at lower pH levels which were nonpermissive for the bactericidal action of cloxacillin, but the effect disappeared at pH 5.0. These findings elucidate previous observations on the protection of intraleukocytic S. aureus from killing by cloxacillin and indicate that low pH in the phagolysosomes may be involved.


Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E W GoodellA Tomasz
Oct 1, 1976·Antimicrobial Agents and Chemotherapy·R LopezA Tomasz
Jul 1, 1973·The Journal of Clinical Investigation·G L Mandell
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·D Horne, A Tomasz
Jan 1, 1981·The Journal of Clinical Investigation·R K RootH L Malech

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