Dec 1, 1975

pH-dependent secretion of procainamide into saliva

Journal of Pharmaceutical Sciences
J R KoupA L Goldfarb

Abstract

The relationship between serum and stimulated, mixed saliva concentrations of procainamide was determined in 12 chronically medicated patients. Samples were obtained at times chosen to approximate the maximum and minimum serum concentrations of the drug during a dosing interval. Marked intersubject variability was found in the ratio of saliva to serum concentration of the drug (0.27-8.93). There was no correlation between the dose (milligrams per kilogram per day) and the minimum serum or saliva concentration of procainamide. Saliva pH ranged from 6.3 to 8.0 in eight subjects. The ratio of saliva to serum concentration of procainamide increased with decreasing pH. This result can be largely explained by the pH-dependent ionization and distribution of procainamide, a weak base.

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References

Mentioned in this Paper

Rhythmin
Saliva - SpecimenType
Process of Secretion
Procainamide Measurement
Saliva
Cell Secretion
Procainamide
Bodily Secretions
Hydrogen-Ion Concentration

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