pH-Dependent silica nanoparticle dissolution and cargo release

Colloids and Surfaces. B, Biointerfaces
Giorgia GiovaninniVladimir Gubala

Abstract

The dissolution of microporous silica nanoparticles (NP) in aqueous environments of different biologically relevant pH was studied in order to assess their potential as drug delivery vehicles. Silica NPs, loaded with fluorescein, were prepared using different organosilane precursors (tetraethoxysilane, ethyl triethoxysilane or a 1:1 molar ratio of both) and NP dissolution was evaluated in aqueous conditions at pH 4, pH 6 and pH 7.4. These conditions correspond to the acidity of the intracellular environment (late endosome, early endosome, cytosol respectively) and gastrointestinal tract ('fed' stomach, duodenum and jejunum respectively). All NPs degraded at pH 6 and pH 7.4, while no dissolution was observed at pH 4. NP dissolution could be clearly visualised as mesoporous hollows and surface defects using electron microscopy, and was supported by UV-vis, fluorimetry and DLS data. The dissolution profiles of the NPs are particularly suited to the requirements of oral drug delivery, whereby NPs must resist degradation in the harsh acidic conditions of the stomach (pH 4), but dissolve and release their cargo in the small intestine (pH 6-7.4). Particle cores made solely of ethyl triethoxysilane exhibited a 'burst release' of encaps...Continue Reading

Citations

Nov 10, 2018·Drug Development and Industrial Pharmacy·Kristen E Bremmell, Clive A Prestidge
Jun 3, 2020·Pharmaceutics·Nerea Iturrioz-RodríguezMónica L Fanarraga
Jun 23, 2019·Analytical and Bioanalytical Chemistry·Otmar GeissJosefa Barrero
Dec 10, 2020·Drug Development and Industrial Pharmacy·Janiele Mayara Ferreira de AlmeidaNedja Suely Fernandes
Dec 20, 2020·International Journal of Molecular Sciences·Ana Rodríguez-RamosMónica L Fanarraga
Dec 5, 2020·Scientific Reports·Giulia Della RosaAlessandra Aloisi
Feb 20, 2021·Molecular Pharmaceutics·Brianna CoteAdam W G Alani
Dec 6, 2019·ACS Applied Materials & Interfaces·Delyan R HristovDavid J Brayden
Aug 19, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Elmar Damasceno JuniorDjalma Ribeiro da Silva

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