pH during non-synaptic epileptiform activity-computational simulations

Physical Biology
A M RodriguesAntônio-Carlos Guimarães de Almeida

Abstract

The excitability of neuronal networks is strongly modulated by changes in pH. The origin of these changes, however, is still under debate. The high complexity of neural systems justifies the use of computational simulation to investigate mechanisms that are possibly involved. Simulated neuronal activity includes non-synaptic epileptiform events (NEA) induced in hippocampal slices perfused with high-K(+) and zero-Ca(2+), therefore in the absence of the synaptic circuitry. A network of functional units composes the NEA model. Each functional unit represents one interface of neuronal/extracellular space/glial segments. Each interface contains transmembrane ionic transports, such as ionic channels, cotransporters, exchangers and pumps. Neuronal interconnections are mediated by gap-junctions, electric field effects and extracellular ionic fluctuations modulated by extracellular electrodiffusion. Mechanisms investigated are those that change intracellular and extracellular ionic concentrations and are able to affect [H(+)]. Our simulations suggest that the intense fluctuations in intra and extracellular concentrations of Na(+), K(+) and Cl(-) that accompany NEA are able to affect the combined action of the Na(+)/H(+) exchanger (NHE),...Continue Reading

References

Mar 1, 1977·The Journal of Physiology·R W Meech, R C Thomas
Oct 1, 1992·Trends in Neurosciences·M Chesler, K Kaila
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K SiesjöM Ingvar
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S Lindskog, J E Coleman
Oct 1, 1967·Physiological Reviews·T H Maren
May 1, 1997·Journal of Neurophysiology·E Pan, J L Stringer
Sep 5, 1997·The Journal of Biological Chemistry·J Orlowski, S Grinstein
Oct 1, 1998·The American Journal of Physiology·J A Hernández, E Cristina
Jul 23, 2002·The Journal of Biological Chemistry·Yoshiko MurataMasamitsu Futai
Apr 12, 2003·Trends in Neurosciences·John A PayneKai Kaila
Aug 21, 2003·The Journal of Biological Chemistry·Shigeo WakabayashiMunekazu Shigekawa
Sep 25, 2003·Physiological Reviews·Mitchell Chesler
Mar 6, 2004·IEEE Transactions on Bio-medical Engineering·A C G AlmeidaA F C Infantosi
Nov 17, 2004·Advances in Physiology Education·Walter F Boron
Apr 14, 2006·Journal of Neurophysiology·Chi-Kun TongMitchell Chesler
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Janet Rennie, Geraldine Boylan
Sep 28, 2007·Computational Biology and Chemistry·Antônio M RodriguesMario A Duarte
Dec 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hemal R PathakDouglas A Coulter
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nataliya SvicharMitchell Chesler
May 23, 2009·Physical Biology·Antônio M RodriguesAntônio-Carlos G de Almeida
Oct 5, 2010·Epilepsia·Else A TolnerKai Kaila
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eva RuusuvuoriKai Kaila
Aug 3, 2011·Nature Reviews. Neurology·Sonia L BonifacioDonna M Ferriero
Apr 25, 2012·Frontiers in Pharmacology·Piotr Bregestovski, Christophe Bernard
Oct 5, 2013·Physical Biology·Mariana Rodrigues LopesAntônio-Carlos Guimarães de Almeida
Mar 5, 2014·Frontiers in Physiology·Vernon A RuffinMark D Parker
Oct 18, 2014·Frontiers in Cellular Neuroscience·Maisa F MirandaLuciene Covolan

❮ Previous
Next ❯

Citations

Dec 17, 2019·Neural Networks : the Official Journal of the International Neural Network Society·Damien DepannemaeckerAntônio-Carlos Guimarães de Almeida
Dec 29, 2020·International Journal of Neural Systems·Antônio Márcio RodriguesAntônio-Carlos Guimarães de Almeida
Jul 6, 2021·Seizure : the Journal of the British Epilepsy Association·Damien DepannemaeckerChristophe Bernard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.