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pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles

The Journal of Clinical Investigation

Apr 1, 1980

J W Blomstedt, P S Aronson

Abstract

The transport mechanism of urate and p-aminohippurate (PAH) was evaluated in microvillus membrane vesicles isolated from the renal cortex of the mongrel dog. Imposition of a transmembrane pH gradient (pHo less than pH1) markedly accelerated the uptake of [14C]urate and [3H]PAH and cause...read more

Mentioned in this Paper

Tissue Membrane
Microvilli
Entire Cortex of Kidney
Urate
Mixed breed dog
Valinomycin
Resting Potentials
Potassium
Uptake
Integral to Membrane
Paper Details
References
  • References4
  • Citations45
1
  • References4
  • Citations45
12345

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Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes

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pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles

The Journal of Clinical Investigation

Apr 1, 1980

J W Blomstedt, P S Aronson

PMID: 7358852

DOI: 10.1172/jci109748

Abstract

The transport mechanism of urate and p-aminohippurate (PAH) was evaluated in microvillus membrane vesicles isolated from the renal cortex of the mongrel dog. Imposition of a transmembrane pH gradient (pHo less than pH1) markedly accelerated the uptake of [14C]urate and [3H]PAH and cause...read more

Mentioned in this Paper

Tissue Membrane
Microvilli
Entire Cortex of Kidney
Urate
Mixed breed dog
Valinomycin
Resting Potentials
Potassium
Uptake
Integral to Membrane

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

The Journal of Clinical Investigation

Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes

The Journal of Clinical InvestigationAugust 1, 1985
S E Guggino, P S Aronson
Pflügers Archiv : European journal of physiology

Transport of p-aminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex

Pflügers Archiv : European journal of physiologyFebruary 24, 1976
W Berner, R Kinne
Paper Details
References
  • References4
  • Citations45
1
  • References4
  • Citations45
12345

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