PMID: 44382Jan 1, 1979

pH homeostasis during cardiopulmonary resuscitation in critically ill patients

L R MartinezS Kountz


We investigated the effect of repeated administration of sodium bicarbonate on acid-base balance and serum chemistry in a group of patients who developed cardiac arrest. A mixed acidosis persisted throughout the duration of resuscitation in the majority of patients in spite of the large ventilatory volume and multiple doses of bicarbonate they received. However, the repeated administration of bicarbonate prevented a severe fall in serum pH. Our study demonstrated the beneficial role of bicarbonate in the treatment of metabolic acidosis associated with cardiac arrest of prolonged duration. Analysis of our data strongly indicated that the primary factors which determine the serum pH during cardiopulmonary resuscitation are the duration of circulatory arrest, adequacy of ventilation and circulation, pH immediately before arrest, and quantity of bicarbonate administered and its volume of distribution in the various fluid and tissue compartments.


Mar 1, 1996·The American Journal of Emergency Medicine·R B VukmirP Safar
Jul 1, 1987·The American Journal of Emergency Medicine·J A AugustineJ B McCabe
Sep 1, 1984·Annals of Emergency Medicine·J T Niemann, J P Rosborough
Nov 1, 1991·Annals of Emergency Medicine·C S FederiukG A Ewy
Jul 2, 2009·The Annals of Pharmacotherapy·Matthew J GeraciJason Persoff


Feb 2, 1976·JAMA : the Journal of the American Medical Association·R L Bishop, M L Weisfeldt
Oct 10, 1974·The New England Journal of Medicine·J P Kassirer
Jul 19, 1973·The New England Journal of Medicine·S GarellaJ A Chazan
Feb 1, 1974·The American Journal of Medicine·J A MáttarL Stein
Feb 1, 1972·The Journal of Clinical Investigation·S Adler
Apr 7, 1966·The New England Journal of Medicine·H L Bleich, W B Schwartz

Related Concepts

Carbonic Acid Ions
Intensive Care Unit
Anion Gap
Blood Gas Analysis
Metabolic Acidosis
Hydrogen-Ion Concentration
Resuscitation Procedure
Cardiac Arrest

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