pH manipulation as a novel strategy for treating mucormycosis

Antimicrobial Agents and Chemotherapy
Wioleta J TrzaskaKerstin Voelz

Abstract

Mucormycosis is a fatal fungal disease caused by several organisms within the order Mucorales. In recent years, traumatic injury has emerged as a novel risk factor for mucormycosis. Current antifungal therapy is ineffective, expensive, and typically requires extensive surgical debridement. There is thus a pressing need for safe prophylactic treatment that can be rapidly and easily applied to high-risk patients, such as those with major trauma injuries. Acetic acid has been used as a topical treatment for burn wounds for centuries and has proven activity against Gram-negative bacteria. Here, we demonstrate that acetic acid is also highly effective against major pathogenic groups of Mucorales, even at very low concentrations (0.3%). This antifungal effect is not seen with other acids, such as hydrochloric and lactic acid, suggesting that acetic acid activity against Mucorales spores is not solely evoked by low environmental pH. In agreement with this, we demonstrate that the antifungal activity of acetic acid arises from a combination of its ability to potently lower intracellular pH and from pH-independent toxicity. Thus, dilute acetic acid may offer a low-cost, safe, prophylactic treatment for patients at risk of invasive mucor...Continue Reading

References

Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carol A Kauffman
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maureen M RodenThomas J Walsh
May 1, 1940·Journal of Bacteriology·A S Levine, C R Fellers
Jan 30, 2008·Antimicrobial Agents and Chemotherapy·Ashraf S IbrahimBrad Spellberg
Jun 24, 2011·PLoS Pathogens·Charles H LiSoo Chan Lee
Jul 26, 2011·International Journal of Antimicrobial Agents·D A EnochJ A Karas
Oct 9, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tyler WarkentienUNKNOWN Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group
Jun 12, 2013·The Journal of Hospital Infection·A P FraiseN Moiemen
Sep 4, 2013·Journal of Infection and Public Health·B S NagobaR C Gandhi
May 16, 2014·Mycoses·Daniela TackeOliver A Cornely
Aug 12, 2014·Mycopathologia·Jong Hun Kim, Kali Williams
Nov 12, 2014·Cold Spring Harbor Perspectives in Medicine·Anuradha ChowdharyG Sybren de Hoog

❮ Previous
Next ❯

Citations

Apr 30, 2016·Injury·Bilal ZahoorDaryl Wall
May 2, 2017·Biological & Pharmaceutical Bulletin·Reiko IkedaKazuki Yanagisawa

❮ Previous
Next ❯

Datasets Mentioned

BETA
CBS277.49

Software Mentioned

NIS Elements

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Médecine sciences : M/S
Olivier Lortholary
Archives of Trauma Research
Cheng Jie Zheng, Albert Y Wu
Critical Care Nurse
Christine Moreno Smith
© 2021 Meta ULC. All rights reserved