PMID: 3466682Feb 1, 1987

Ph-positive chronic myeloid leukemia with near-haploid conversion in vivo and establishment of a continuously growing cell line with similar cytogenetic pattern

Cancer Genetics and Cytogenetics
B S AnderssonK B McCredie

Abstract

Blast cells from a 39-year-old man in the blastic phase of chronic myeloid leukemia, with a benign phase of 15 years duration, as well as a cell line arising from this cell population, were studied. Cellular morphology, cytochemical staining pattern, and absence of terminal deoxynucleotidyl transferase showed the blast cells to be of myeloid character. Cytogenetic studies revealed the presence of two near-haploid cell populations with +8 and +8, +15, respectively, both of them containing the translocation t(9;22) in the original tumor cell sample. The cell line derived from this patient's leukemic cell sample contained both near-haploid and hyperdiploid clones, the hyperdiploid clones being multiples of the near-haploid clone(s). All of the clones carried the t(9;22) in the form of a Philadelphia chromosome.

References

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Citations

Aug 1, 1987·Cancer Genetics and Cytogenetics·M BlickJ Gutterman
Dec 7, 2013·Epigenetics & Chromatin·Martin Leeb, Anton Wutz
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Anton Wutz
Feb 9, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Richard T TimmsPaul J Lehner
Dec 17, 2015·RNA Biology·Aleksandra E KornienkoFlorian M Pauler
Dec 1, 1987·Baillière's Clinical Haematology·A Hagemeijer
Mar 11, 2004·British Journal of Haematology·Nada OrsolicSrdan Verstovsek
Nov 18, 2015·Nature Chemical Biology·Sebastian M B Nijman
Jun 5, 2015·Mutation Research. Reviews in Mutation Research·Hua ShenLuoping Zhang
Oct 29, 2013·Nature Methods·Tilmann BürckstümmerSebastian M B Nijman
Dec 1, 1995·Leukemia & Lymphoma·H T Hassan, H G Drexler
May 14, 1998·European Journal of Haematology·C GidlöfT H Tötterman
Oct 3, 2020·Computational and Structural Biotechnology Journal·Shengyi SunLing Shuai

Related Concepts

Blast Phase
Chromosome Banding
Genetic Markers
Karyotype Determination Procedure
Leukemia, Monocytic, Chronic
Philadelphia Chromosome
Ploidies

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