pH Regulates White-Opaque Switching and Sexual Mating in Candida albicans

Eukaryotic Cell
Yuan SunGuanghua Huang

Abstract

As a successful commensal and pathogen of humans, Candida albicans encounters a wide range of environmental conditions. Among them, ambient pH, which changes frequently and affects many biological processes in this species, is an important factor, and the ability to adapt to pH changes is tightly linked with pathogenesis and morphogenesis. In this study, we report that pH has a profound effect on white-opaque switching and sexual mating in C. albicans. Acidic pH promotes white-to-opaque switching under certain culture conditions but represses sexual mating. The Rim101-mediated pH-sensing pathway is involved in the control of pH-regulated white-opaque switching and the mating response. Phr2 and Rim101 could play a major role in acidic pH-induced opaque cell formation. Despite the fact that the cyclic AMP (cAMP) signaling pathway does not play a major role in pH-regulated white-opaque switching and mating, white and opaque cells of the cyr1/cyr1 mutant, which is defective in the production of cAMP, showed distinct growth defects under acidic and alkaline conditions. We further discovered that acidic pH conditions repressed sexual mating due to the failure of activation of the Ste2-mediated α-pheromone response pathway in opaque A...Continue Reading

References

Jun 25, 1998·Infection and Immunity·F De BernardisW A Fonzi
Jan 11, 2000·Molecular and Cellular Biology·D DavisA P Mitchell
Jun 10, 2000·Molecular and Cellular Biology·A El BarkaniF A Mühlschlegel
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yu LanNina Agabian
Jun 11, 2003·Eukaryotic Cell·David R SollRui Zhao
Oct 31, 2003·Molecular and Cellular Biology·Richard J BennettAlexander D Johnson
Dec 11, 2003·Eukaryotic Cell·Sneh L PanwarPaul T Magee
Jun 7, 2005·Current Biology : CB·Alistair M Hetherington, John A Raven
Nov 24, 2005·Current Biology : CB·Torsten KlengelFritz A Mühlschlegel
Aug 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rebecca E ZordanAlexander D Johnson
Aug 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Guanghua HuangHaoping Liu
Sep 5, 2006·Eukaryotic Cell·Thyagarajan SrikanthaDavid R Soll
May 18, 2007·Annual Review of Microbiology·Malcolm Whiteway, Catherine Bachewich
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Subhrajit BiswasAsis Datta
May 7, 2008·Trends in Microbiology·Miguel A PeñalvaHerbert N Arst
Feb 10, 2009·Current Biology : CB·Guanghua HuangDavid R Soll
Sep 12, 2009·FEMS Yeast Research·David R Soll
Oct 27, 2009·Current Opinion in Microbiology·Matthew B Lohse, Alexander D Johnson
Sep 28, 2010·Acta Biochimica Et Biophysica Sinica·Xinyi NieJiangye Chen
May 25, 2012·Molecular Biology of the Cell·Han DuGuanghua Huang
Jul 19, 2012·Communicative & Integrative Biology·Shamoon NaseemJames B Konopka
Jan 26, 2013·Scientifica·James B Konopka
Jan 21, 2014·Eukaryotic Cell·Muriel Cornet, Claude Gaillardin

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Citations

May 8, 2016·Cellular Microbiology·C BraunsdorfM Schaller
Nov 20, 2015·Current Genetics·Han Du, Guanghua Huang
Nov 22, 2016·Nature Reviews. Microbiology·Suzanne M NobleJessica N Witchley
Jan 18, 2018·Pathogens·Christina Braunsdorf, Salomé LeibundGut-Landmann
Oct 17, 2017·Molecular Microbiology·Qiushi ZhengGuanghua Huang
May 17, 2017·Antimicrobial Agents and Chemotherapy·Veronica B CraikMatthew B Lohse
Jan 19, 2018·Scientific Reports·Siwy Ling YangYue Wang
Apr 11, 2019·Acta Biochimica Et Biophysica Sinica·Jiao GongGuanghua Huang
Dec 28, 2019·Journal of Fungi·Kyunghun MinJames B Konopka
May 7, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ifeanyi Elibe Mba, Emeka Innocent Nweze
Jun 4, 2020·G3 : Genes - Genomes - Genetics·Lucas R BrenesAlexander D Johnson
Feb 13, 2020·Frontiers in Cellular and Infection Microbiology·Fabien Cottier, Rebecca A Hall
Apr 2, 2021·G3 : Genes - Genomes - Genetics·Anna Carolina Borges Pereira CostaMalcolm Whiteway

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