pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design

Designed Monomers and Polymers
Ghulam AbbasMahtab Ahmad Khan

Abstract

Aim of the present work was to develop alginate raft forming tablets for controlled release pantoprazole sodium sesquihydrate (PSS). Box behnken design was used to optimize 15 formulations with three independent and three dependent variables. Physical tests of all formulations were within pharmacopoeial limits. Raft was characterized by their strength, thickness, resilience, acid neutralizing capacity, floating lag time and total floating time. Raft strength, thickness and resilience of optimized formulation AR9 were 7.43 ± 0.019 g, 5.8 ± 0.245 cm and greater than 480 min, respectively. Buffering and neutralizing capacity were 11.2 ± 1.01 and 6.5 ± 0.56 meq, respectively. Dissolution studies were performed by using simulated gastric fluid pH 1.2 and cumulative percentage release of optimized formulation AR9 was found 98%. First order release kinetics were followed and non-fickian diffusion was observed as value of n was greater than 0.45 in korsmeyer-peppas model. PSS, polymers, tablets and rafts were further characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). FTIR spectra of PSS, polymers and raft of optimized formulation AR9 showed peaks at 3...Continue Reading

References

Feb 15, 2005·International Journal of Pharmaceutics·V ZupancicF Vrecer
Apr 9, 2005·International Journal of Pharmaceutics·F C HampsonP W Dettmar
Jul 17, 2007·Journal of Pharmaceutical and Biomedical Analysis·Ganta Madhusudhan ReddyK Mukkanti
Jul 1, 2008·International Journal of Pharmaceutics·Inéz Jiménez-MartínezLeopoldo Villafuerte-Robles
Nov 21, 2009·Drug Development and Industrial Pharmacy·Frank C HampsonPeter W Dettmar
Jul 6, 2012·Drug Development and Industrial Pharmacy·Kishore RapoluPrakash V Diwan
Jan 15, 2013·European Journal of Medicinal Chemistry·S JoseE B Souto
Mar 19, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vipul D PrajapatiBhumi S Zala
Apr 13, 2013·International Journal of Pharmaceutical Investigation·Shailesh T PrajapatiChhagan N Patel
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Anirbandeep BoseNavjot Singh
Nov 28, 2013·Carbohydrate Polymers·Andréia Bagliotti MeneguinRaul Cesar Evangelista
Jul 6, 2014·International Journal of Biological Macromolecules·Sun Woo JangMyung Joo Kang
Jul 6, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nattha KerdsakundeeRuedeekorn Wiwattanapatapee
Aug 8, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Péter DiósAttila Dévay
May 24, 2016·International Journal of Biological Macromolecules·D Sathya SeeliM Prabaharan

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Citations

Aug 25, 2017·Drug Development and Industrial Pharmacy·Peter W DettmarMark Potts
Aug 8, 2018·Drug Development and Industrial Pharmacy·Ghulam Abbas, Muhammad Hanif
Dec 21, 2019·Pharmaceutical Development and Technology·Sara ShakhwarAhmed Abu Fayyad

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Methods Mentioned

BETA
infrared spectroscopy
differential scanning calorimetry
X-ray

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