pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

Chemical Communications : Chem Comm
Renata NegriniRaffaele Mezzenga

Abstract

A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.

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Citations

Jan 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Mar 1, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wye-Khay FongCornelia B Landersdorfer
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Apr 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Reza GhanbariRaffaele Mezzenga
Jun 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Rama PrajapatiStefan Salentinig
Oct 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yawen LiAihua Zou
Oct 3, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
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