pH-Responsive Porous Nanocapsules for Controlled Release

Chemistry : a European Journal
Jun SongMing Ou

Abstract

In this work pH-responsive porous nanocapsules have been successfully prepared from a ternary graft copolymer, poly(glycidyl methacrylate)-g-[poly(2-cinnamoyloxyethyl methacrylate)-r-poly(ethylene glycol) methyl ether-r-poly(2-diethylaminoethyl methacrylate)] or PGMA-g-(PCEMA-r-MPEG-r-PDEAEMA). The graft copolymers were fabricated by grafting three types of polymer chains onto the backbone polymer by using click chemistry. These ternary copolymers underwent self-assembly to form vesicles in a DMF/water solvent mixture. While the MPEG chains served as the corona and stabilized the vesicles, the vesicle wall was composed of a dominant PCEMA continuous phase that was interspersed by PDEAEMA domains. After photo-cross-linking, the PDEAEMA domains were embedded in the structurally locked PCEMA wall. By decreasing the pH of the external solution, we were able to trigger the release of encapsulated pyrene due to the capsule wall becoming porous as a result of the PDEAEMA chains bearing positively charged amine groups stretching into the water. While these pH-responsive porous nanocapsules exhibited potential applications in drug delivery, detection and catalysis, the strategy reported in this contribution also represented a new paradi...Continue Reading

References

Dec 1, 1982·Journal of Pharmaceutical Sciences·S K Chandrasekaran, D R Paul
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Mar 19, 2002·International Journal of Pharmaceutics·Yvette N KonanEric Allémann
Aug 29, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Patrick CouvreurChristine Vauthier
Jul 20, 2004·Angewandte Chemie·Claire S Peyratout, Lars Dähne
Oct 6, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·J I AmalvyY Duccini
Nov 18, 2004·Bioconjugate Chemistry·Elizabeth R GilliesJean M J Fréchet
Dec 22, 2005·Journal of the American Chemical Society·Jianzhong DuSteven P Armes
Jan 10, 2006·Biomacromolecules·Alexander N ZelikinFrank Caruso
Aug 5, 2006·Biochimica Et Biophysica Acta·Andreas FritzeRegine Peschka-Süss
Aug 2, 2007·Chemical Communications : Chem Comm·Brian G TrewynVictor S-Y Lin
Feb 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas GantaMansoor Amiji
May 17, 2008·Angewandte Chemie·Jung-Keun KimMyongsoo Lee
Sep 23, 2008·Angewandte Chemie·Sergey A Dergunov, Eugene Pinkhassik
Aug 1, 2007·ACS Nano·Alexander N ZelikinFrank Caruso
Jan 23, 2010·Nature Materials·Martien A Cohen StuartSergiy Minko
Jun 23, 2010·Journal of the American Chemical Society·Wanji Seo, Scott T Phillips
Jun 24, 2010·Journal of the American Chemical Society·Nadezda FominaAdah Almutairi
Jul 29, 2010·Journal of the American Chemical Society·Aaron P Esser-KahnJeffrey S Moore
Nov 30, 2010·Chemical Communications : Chem Comm·Kyle E BroadersJean M J Fréchet
May 11, 2011·Biomacromolecules·Sophie MongeJean-Jacques Robin
Feb 18, 2009·Macromolecular Rapid Communications·Adam BlanazsAnthony J Ryan
Oct 15, 2011·Advanced Drug Delivery Reviews·Arnaud E FelberJean-Christophe Leroux
Mar 22, 2012·Journal of the American Chemical Society·Demetra S AchilleosMaria Vamvakaki
May 19, 2012·Chemical Reviews·Dingcai WuKrzysztof Matyjaszewski
Jan 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hugo OliveiraSébastien Lecommandoux
Sep 18, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Alireza AbbaspourradDavid A Weitz
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Feb 18, 2014·Biomacromolecules·Feng LiuLei Miao
Aug 26, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yue LuZhen Gu
Dec 10, 2015·IET Nanobiotechnology·Imran KhanDeog-Hwan Oh

❮ Previous
Next ❯

Citations

Feb 23, 2021·Computers in Biology and Medicine·G PontrelliC Chatgilialoglu
Mar 7, 2021·Polymers·Xiao WangXuefeng Gui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Lei MiaoHongsheng Luo
Journal of Polymer Science. Part A-1, Polymer Chemistry
K KojimaE Masuhara
© 2022 Meta ULC. All rights reserved