pH-responsive stealth micelles composed of cholesterol-modified PLA as a nano-carrier for controlled drug release

Progress in Biomaterials
Massoumeh BagheriZhaleh Pourmoazzen

Abstract

Present research is a preliminary report on the novel pH-responsive micelles based on an amphiphilic brush copolymer P(PEGMA)-b-P(DMAEMA-co-CPLAMA) used as the promising drug carrier. The copolymer was synthesized using cholesteryl poly(L-lactic acid) methacrylate (CPLAMA), poly(ethylene glycol) monomethyl ether methacrylate (PEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) with appropriate hydrophobic/hydrophilic ratios via atom transfer radical polymerization. The copolymer compositions were determined by 1H NMR. The synthesized copolymer self-assembled into nano-scale micelles capable of encapsulating hydrophobic model drug naproxen in their hydrophobic cores in aqueous solutions. pH sensitivity and self-assembly behaviors of copolymer were studied by UV-vis transmittance, fluorescence spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering. The results showed that the copolymer had high pH responsivity with a phase transition pH around pH 6.2. The critical micelle concentrations at pH 6.5 were found about 2.4 mg L-1. The stable and small micelles were obtained at pH 5.5-6.5. Upon increasing pH higher than 7, the single micelles further assembled into the micellar aggregates. TEM images of co...Continue Reading

References

Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Oct 15, 2011·Advanced Drug Delivery Reviews·Arnaud E FelberJean-Christophe Leroux
Jun 18, 2001·Angewandte Chemie·Shiyong LiuSteven P Armes

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Methods Mentioned

BETA
NMR
transmission electron microscopy

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