pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy

ACS Applied Materials & Interfaces
Wei ChengXiaowei Zeng

Abstract

In this study, we introduced a targeting polymer poly(ethylene glycol)-folic acid (PEG-FA) on the surface of polydopamine (PDA)-modified mesoporous silica nanoparticles (MSNs) to develop the novel nanoparticles (NPs) MSNs@PDA-PEG-FA, which were employed as a drug delivery system loaded with doxorubicin (DOX) as a model drug for cervical cancer therapy. The chemical structure and properties of these NPs were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, N2 adsorption/desorption, dynamic light scattering-autosizer, thermogravimetric analysis, and Fourier transform infrared spectroscopy. The pH-sensitive PDA coating served as a gatekeeper. The in vitro drug release experiments showed pH-dependent and sustained drug release profiles that could enhance the therapeutic anticancer effect and minimize potential damage to normal cells due to the acidic microenvironment of the tumor. These MSNs@PDA-PEG-FA achieved significantly high targeting efficiency, which was demonstrated by the in vitro cellular uptake and cellular targeting assay. Compared with that of free DOX and DOX-loaded NPs without the folic targeting ligand, the FA-targeted NPs exhibited higher antitumor efficacy in vivo, implying that...Continue Reading

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Citations

Jul 25, 2017·Nanomaterials·Anna Watermann, Juergen Brieger
Feb 3, 2018·Cancer Chemotherapy and Pharmacology·Zhi LiuJiandong Wang
Nov 11, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Ziwei DengBo Peng
Mar 7, 2019·Biomaterials Science·Rushikesh S Ambekar, Balasubramanian Kandasubramanian
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Jan 1, 2019·Cancer Nanotechnology·Lindsey A BennieJonathan A Coulter
Aug 8, 2019·Journal of Biomedical Materials Research. Part a·Md AquibBo Wang
Jan 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaowu ZhouLinyong Zhu
Apr 24, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Chao ChenPing Wang
May 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qingfei ZhangYubin Huang
Aug 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ryoko M UdaKeita Hayashi
Sep 25, 2020·Expert Opinion on Drug Delivery·Joydeb Majumder, Tamara Minko
Jan 13, 2018·Frontiers in Bioengineering and Biotechnology·Raquel VinhasPedro V Baptista
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May 13, 2020·Chemical Society Reviews·Chao ZhangZuankai Wang
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Jan 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu ZhangJiang Chang
Jun 2, 2020·Biotechnology Journal·Jorge Parra-NietoAlejandro Baeza
Sep 25, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kun MaChuanbin Mao

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