pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles

International Journal of Biological Macromolecules
Hongyu ChenBingbing Jiang

Abstract

In this work, a novel pH-sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles (MSNs), DOX@MSN-DDA-CL, are prepared. The dextrin grafting on the surface of MSNs is oxidized by KIO4 to obtain dextrin dialdehyde, which is then cross-linked by tetraethylenepentamine through a pH-sensitive Schiff's base. Under physiological conditions, the cross-linked dextrin dialdehyde blocks the pores to prevent premature release of model drug doxorubicin hydrochloride (DOX). In the weak acidic environment, pH 6.0 in this work, the Schiff's base can be hydrolyzed and released the drug. The in vitro drug release studies at different pHs prove the pH-sensitivity of DOX@MSN-DDA-CL. The cytotoxicity and cell internalization behavior are also investigated in detail. In vivo tissue distribution and pharmacokinetics with a H22-bearing mouse animal mode are also studied, prove that DOX@MSN-DDA-CL has a longer retention time than that of pure DOX and can accumulate in tumor region via enhanced permeation and retention and nanomaterials-induced endothelial cell leakiness effects. In conclusion, the pH-sensitive modified dextrin/MSNs complex drug delivery system has a great potential for cancer therapy.

References

Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Mar 12, 2009·Journal of the American Chemical Society·Juan L Vivero-EscotoVictor S-Y Lin
Mar 29, 2014·Small·Jonas CroissantJeffrey I Zink

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Citations

Feb 9, 2017·International Journal of Biological Macromolecules·Min ZhangBingbing Jiang
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Sep 28, 2017·Bioengineering·Miguel Gisbert-GarzaránMaría Vallet-Regí
Feb 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ZhuQunwei Xu
Dec 11, 2020·Expert Opinion on Drug Delivery·Jiani DongQubo Zhu
Dec 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shijie ZhuoXiaowen Liu
Jul 24, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohsen Khodadadi YazdiMasoud Mozafari

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