PMID: 29115Sep 1, 1978Paper

pH-solubility profiles or organic carboxylic acids and their salts

Journal of Pharmaceutical Sciences
Z T Chowhan

Abstract

The solubilities of naproxen, 7-methylsulfinyl-2-xanthonecarboxylic acid, 7-methylthio-2-xanthonecarboxylic acid, and their sodium, potassium, calcium, and magnesium salts were determined as a function of pH. The results on the solubility of naproxen and its salts were in excellent agreement with the theoretical profiles describing the relationship between pH values of the solutions and the dissociation constant of the acid. The solubilities of the two xanthonecarboxylic acids were higher at higher pH values than the values calculated when complete dissociation in solution was assumed. The influence of the salt species on the solubility of organic carboxylic acids, at and above pH values of complete ionization, cannot be predicted even qualitatively from equations used for alkali and alkaline earth metal salts.

Citations

Feb 1, 1983·Digestive Diseases and Sciences·J N HuntC L Jiang
Sep 5, 2001·International Journal of Pharmaceutics·K M O'Connor, O I Corrigan
Sep 16, 1999·International Journal of Pharmaceutics·W H Streng
Dec 20, 2012·AAPS PharmSciTech·Lokesh KumarArvind K Bansal
Mar 3, 2012·Drug Development and Industrial Pharmacy·Benjamin M CollmanAnthony C Blackburn
Sep 18, 2008·Drug Development and Industrial Pharmacy·Xiaoxia ChenRobert O Williams
Nov 29, 2011·Drug Development and Industrial Pharmacy·S E DavidB R Conway
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·V Hayden ThomasAyman El-Kattan
Aug 1, 1985·Journal of Pharmaceutical Sciences·B D Anderson, R A Conradi
Jan 18, 2014·Journal of Pharmaceutical Sciences·Dhara RaijadaJukka Rantanen
Dec 4, 2003·Journal of Pharmaceutical Sciences·Liang FangYasunori Morimoto
May 28, 2005·Journal of Pharmaceutical Sciences·Shoufeng LiAbu T M Serajuddin
Dec 1, 1991·Journal of Pharmaceutical Sciences·G BettinettiF Giordano
Jul 24, 2007·Advanced Drug Delivery Reviews·Alex Avdeef
Jul 10, 2007·Advanced Drug Delivery Reviews·Abu T M Serajuddin
Oct 24, 2006·Drug Discovery Today·Shobha N BhattacharJames A Wesley
Jul 16, 2010·Analytica Chimica Acta·Gergely VölgyiKrisztina Takács-Novák
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Kiyohiko SuganoTakashi Mano
May 31, 2016·Journal of Pharmaceutical Sciences·Stephen J FranklinPaul B Myrdal
Sep 17, 2016·The Journal of Physical Chemistry Letters·Delanie J LoseyMiriam Arak Freedman
Feb 6, 2017·Journal of Pharmaceutical Sciences·Yan HeEdward Orton
Sep 14, 2017·ChemMedChem·Dana J LevineJeffrey R Long
Oct 12, 2018·Pharmaceutical Development and Technology·Aymeric OussetKalliopi Dodou
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Mar 10, 2017·Drug Development and Industrial Pharmacy·Haichen NieQi Tony Zhou
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Deepak GuptaSheeba Varghese Gupta
Nov 20, 2020·Journal of Hazardous Materials·Kaihang ZhangJohn C Crittenden
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Huixiang Zhang, Onofrio Annunziata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.