pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

ACS Omega
Fajar R WibowoRonny Martien

Abstract

In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer-Emmett-Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles follo...Continue Reading

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Citations

Aug 23, 2020·Nanomaterials·Jaswinder Sharma, Georgios Polizos
Jun 12, 2020·Pharmaceutics·Sugata Barui, Valentina Cauda
Apr 17, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zhaleh GhafarySudabeh Mafakheri
Aug 30, 2021·Advances in Colloid and Interface Science·Bijaideep DuttaP A Hassan

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Methods Mentioned

BETA
X-ray
scanning
transmission electron microscopy
dynamic light scattering

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