PMID: 11338929May 8, 2001Paper

Phage as gene delivery vectors

Current Opinion in Molecular Therapeutics
P MonaciL Fontana

Abstract

Bacteriophage can be considered as a natural system to efficiently condense and package DNA. They tolerate many different types of mutations, including those that lead to the display of polypeptides as a fusion to any of the structural proteins comprising the phage particle. In addition, they are a powerful biological system for generating and screening mutants with the desired functional properties. It has also been shown that phage vectors can be engineered for receptor-mediated gene transfer to mammalian cells. The attractive features offered by this system have paved the way for various attempts to develop phage as a vector for gene therapy applications.

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