PMID: 11920646Mar 29, 2002Paper

Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine p815 model

International Journal of Cancer. Journal International Du Cancer
Yu-Zhang WuYang Tan

Abstract

The efficacy of phage display particles expressing tumor antigen P1A35-43 in inducing protective and therapeutic anti-tumor immune responses were studied. A protective immune response against a lethal progressive P815 mastocytoma tumor cell challenge was established after subcutaneous injection of phage display particles. Furthermore, the vaccine suppressed growth of pre-existing tumors. Immunization with the hybrid phage particles elicited P1A(35-43) specific CTL responses and a Th1-dominated immune response with phage particle-specific secretion of IFN-gamma but not IL-4. Our results indicate that phage display particles might be a useful vaccine form for tumor-associated antigen epitopes in tumor immunotherapy.

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Sep 13, 2006·Cancer Immunology, Immunotherapy : CII·Fredrik ErikssonPavel Pisa
Sep 15, 2011·Applied Biochemistry and Biotechnology·Aylin Ozdemir BahadirBerrin Erdag
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Oct 18, 2018·Cancer Immunology Research·Caterina BartolacciAugusto Amici

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