PMID: 26889738DOI: 10.1039/c5ob02646fFeb 19, 2016Paper
Phage-displayed macrocyclic glycopeptide libraries
Organic & Biomolecular Chemistry
Simon Ng, Ratmir Derda
Abstract
In this report, we describe an efficient way to generate libraries of macrocyclic glycopeptides in one step by reacting phage-displayed libraries of peptides with dichloro-oxime derivatives. We showed that the reactions do not interfere with the ability of phage to replicate in bacteria. The reactions are site-selective for phage-displayed peptides and they do not modify any other proteins of phage. The technology described in this report will be instrumental for genetic selection of macrocyclic glycopeptides for diverse glycan-binding proteins.
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