Phage-displayed macrocyclic glycopeptide libraries

Organic & Biomolecular Chemistry
Simon Ng, Ratmir Derda

Abstract

In this report, we describe an efficient way to generate libraries of macrocyclic glycopeptides in one step by reacting phage-displayed libraries of peptides with dichloro-oxime derivatives. We showed that the reactions do not interfere with the ability of phage to replicate in bacteria. The reactions are site-selective for phage-displayed peptides and they do not modify any other proteins of phage. The technology described in this report will be instrumental for genetic selection of macrocyclic glycopeptides for diverse glycan-binding proteins.

References

May 1, 1996·Molecular Diversity·S J McConnellD G Spinella
Jul 13, 2001·Journal of the American Chemical Society·Z J Gartner, D R Liu
Apr 3, 2003·Chemistry & Biology·Shuwei Li, Richard W Roberts
Apr 21, 2004·Nature Biotechnology·Samu MelkkoDario Neri
Sep 9, 2004·Science·Loren D WalenskyStanley J Korsmeyer
Sep 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Richard J ClarkDavid J Craik
Oct 20, 2007·Journal of the American Chemical Society·Scott C MeyerIndraneel Ghosh
Nov 17, 2007·Nature Protocols·Carol M Y LeeDaniel Christ
Dec 25, 2007·ACS Chemical Biology·Daniel A Erlanson
Jul 2, 2008·Nature Reviews. Drug Discovery·Edward M DriggersNicholas K Terrett
Jun 2, 2009·Nature Chemical Biology·Christian HeinisGreg Winter
Jun 24, 2011·Nature Chemistry·Christopher J White, Andrei K Yudin
Apr 9, 2013·Journal of the American Chemical Society·Shiyu ChenChristian Heinis
Jul 23, 2013·Bioorganic & Medicinal Chemistry Letters·Kanako AraiHisakazu Mihara
Sep 21, 2013·Journal of Medicinal Chemistry·Fabrizio Giordanetto, Jan Kihlberg
Sep 21, 2013·Drug Discovery Today·Maryam Hamzeh-MivehroudSiavoush Dastmalchi
Jan 24, 2014·Angewandte Chemie·Shiyu ChenChristian Heinis
Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuuki TokunagaMasumi Taki
May 23, 2014·Journal of the American Chemical Society·Pavel I KitovRatmir Derda
Jul 21, 2014·Nature Chemical Biology·Elizabeth A VillarAdrian Whitty
Jul 21, 2014·Nature Chemical Biology·Jason GavenonisJoshua A Kritzer
Oct 8, 2014·Angewandte Chemie·Timothy A HillDavid P Fairlie
Jan 27, 2015·Methods in Molecular Biology·Shiyu Chen, Christian Heinis
Jan 27, 2015·Methods in Molecular Biology·Simon NgRatmir Derda
Feb 19, 2015·Bioconjugate Chemistry·Jaymes BeechKimberly A Kelly
Mar 15, 2015·Current Opinion in Chemical Biology·Christian Heinis, Greg Winter
Apr 11, 2015·Journal of the American Chemical Society·Simon NgRatmir Derda
Apr 26, 2015·Expert Opinion on Drug Discovery·Kobra Omidfar, Maryam Daneshpour
Jun 23, 2015·Angewandte Chemie·Naila AssemPhilip E Dawson
Dec 20, 2015·Journal of the American Chemical Society·Katrina F TjhungRatmir Derda

❮ Previous
Next ❯

Citations

Jan 27, 2017·Annual Review of Food Science and Technology·H AnanyM W Griffiths
Nov 2, 2016·Organic & Biomolecular Chemistry·N Chen, J Xie
Sep 8, 2017·Organic & Biomolecular Chemistry·Vivian Triana, Ratmir Derda
Aug 10, 2019·Angewandte Chemie·Xiaoshan Shayna WangWenshe Ray Liu
Jun 1, 2016·Chemical Science·S Kalhor-MonfaredR Derda
May 2, 2018·Nature Chemistry·Sangram S KaleChristian Heinis
May 17, 2019·International Journal of Molecular Sciences·Andy Chi-Lung LeeJi-Hong Hong
Jan 26, 2021·European Journal of Medicinal Chemistry·Valentina SalaAlessandra Ghigo
Nov 18, 2020·Nature Biotechnology·Shiyu ChenMatthew Bogyo
Jan 30, 2021·Biotechnology Advances·Hanna DotterAnn-Christin Eder
Aug 8, 2017·Current Opinion in Biotechnology·Louise J WalportHiroaki Suga
Feb 16, 2019·Journal of the American Chemical Society·Alexander A VinogradovHiroaki Suga
Nov 11, 2020·ACS Combinatorial Science·Sabrina E IskandarAlbert A Bowers
Jul 19, 2019·Chemical Reviews·Hoi Yee ChowXuechen Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.