Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes

Journal of Bacteriology
Yu-Fan TsaoKaren Maxwell

Abstract

The viruses that infect bacteria, known as phages, play a critical role in controlling bacterial populations in many diverse environments, including the human body. This control stems not only from phages killing bacteria but also from the formation of lysogens. In this state, the phage replication cycle is suppressed, and the phage genome is maintained in the bacterial cell in a form known as a prophage. Prophages often carry genes that benefit the host bacterial cell, since increasing the survival of the host cell by extension also increases the fitness of the prophage. These highly diverse and beneficial phage genes, which are not required for the life cycle of the phage itself, have been referred to as "morons," as their presence adds "more on" the phage genome in which they are found. While individual phage morons have been shown to contribute to bacterial virulence by a number of different mechanisms, there have been no systematic investigations of their activities. Using a library of phages that infect two different clinical isolates of P. aeruginosa, PAO1 and PA14, we compared the phenotypes imparted by the expression of individual phage morons. We identified morons that inhibit twitching and swimming motilities and obs...Continue Reading

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Citations

Feb 6, 2020·Microbial Genomics·Siân V OwenJay C D Hinton
Jun 24, 2020·Antibiotics·Christine PourcelLibera Latino
Jul 14, 2020·Genome Biology and Evolution·Krzysztof FiedorukRobert Bucki
Dec 3, 2020·Expert Review of Anti-infective Therapy·Amrita PatilSunil Saroj
Jan 8, 2021·Molecular Cell·Megha ShahKaren L Maxwell
Jan 22, 2021·Archives of Microbiology·Sabrina RoyerDeivid William da Fonseca Batistão
Apr 9, 2021·Annals of the New York Academy of Sciences·Luke N YaegerLori L Burrows

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