"Phage Transplantation in Allotransplantation": Possible Treatment in Graft-Versus-Host Disease?

Frontiers in Immunology
Andrzej GórskiJan Borysowski

Abstract

Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD.

References

Aug 18, 2001·Bone Marrow Transplantation·V RatanatharathornJ P Uberti
Mar 13, 2003·Kidney International·Karen E PaisleyAngela C Shore
Mar 5, 2005·Cellular and Molecular Life Sciences : CMLS·Andrzej Górski, Beata Weber-Dabrowska
Feb 1, 2006·Medical Microbiology and Immunology·Anna PrzerwaAndrzej Górski
Mar 1, 2006·Transplantation Proceedings·A GórskiM Nowaczyk
Mar 24, 2006·FEMS Immunology and Medical Microbiology·Andrzej GórskiRyszard Miedzybrodzki
Jul 27, 2007·Annals of Hematology·Johnny AmerEitan Fibach
Apr 11, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jan Borysowski, Andrzej Górski
Apr 8, 2009·Clinical and Experimental Medicine·Ryszard MiedzybrodzkiAndrzej Górski
Jun 23, 2011·International Journal of Nephrology and Renovascular Disease·Hernán Trimarchi
Jul 4, 2012·Advances in Virus Research·Andrzej GórskiDanuta Kłosowska
Jul 4, 2012·Advances in Virus Research·Ryszard MiędzybrodzkiAndrzej Górski
Feb 6, 2013·Clinical and Experimental Immunology·S IwamotoY Komada
Aug 27, 2013·PloS One·Paulina MiernikiewiczAndrzej Górski
Aug 28, 2013·The Journal of Experimental Medicine·Dragana JankovicRobert Zeiser
Oct 29, 2013·Lancet·Tayfun GüngörUNKNOWN Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation
Dec 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong LiangHaiyan Liu
Apr 8, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ivana DevicRichard B Presland
Nov 16, 2014·Blood·Mary E D Flowers, Paul J Martin
Apr 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keon-Il ImSeok-Goo Cho
Jul 30, 2016·Frontiers in Microbiology·Paulina MiernikiewiczKrystyna Dąbrowska
Oct 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suelen Martins PerobelliAdriana Bonomo
Nov 20, 2016·Blood·Jonathan U PeledRobert R Jenq
Apr 25, 2017·Future Microbiology·Andrzej GórskiJan Borysowski
Jun 4, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kosuke YoshiokaKazuteru Ohashi
Sep 1, 2017·Immunological Reviews·Jeremy J Barr

❮ Previous
Next ❯

Citations

Jul 1, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Olga Maria RostkowskaMagdalena Durlik
Jan 12, 2021·Frontiers in Immunology·Rachel E CrosslandMagdalena Grce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.