PMID: 9524441Apr 1, 1997Paper

Phagocyte-bacteria interactions

Advances in Dental Research
Y KeisariI Ofek

Abstract

Recognition and phagocytosis of micro-organisms in a serum-poor environment represent innate immunity against many extracellular pathogens. As a paradigm for such processes, we discuss the recognition of Klebsiella pneumoniae by alveolar macrophages and monocyte-derived macrophages in the absence of serum. Macrophages recognize and subsequently kill Klebsiella expressing Man-alpha 2/3-Man or Rha-alpha 2/3-Rha sequences in their capsular polysaccharides by two mechanisms: (a) recognition of the capsular structures by macrophage mannose receptors, and (b) opsonization by the lung surfactant protein A (SP-A), which binds to the capsular polysaccharides of Klebsiella and to SP-A receptors on the macrophages. Sp-A may also enhance phagocytosis by increasing the activity of macrophage mannose receptors. We conclude that a specific microbial surface structure may be a target for recognition by macrophages via several mechanisms, as exemplified in the case of Klebsiella capsular polysaccharides. Multiple recognition mechanisms of pathogens by macrophages may be essential to provide innate immunity to reduce the frequency of infections caused by a relatively less virulent bacterium in the immuno-compromised host.

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Citations

Nov 18, 2003·American Journal of Respiratory and Critical Care Medicine·Philipp MarkartHenry T Akinbi
Mar 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Philip J O'ReillySadis Matalon
Oct 18, 2011·Paediatric Drugs·Shruti Agrawal, Simon Nadel
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Dec 14, 2004·Molecular Immunology·Hitomi Sano, Yoshio Kuroki
Apr 6, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chang-Phone FungL Kristopher Siu
May 1, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Francinete Carla Nunes CavalcantiAna Catarina de Souza Lopes
Dec 25, 2007·Experimental Biology and Medicine·June Hsieh WuTing-Shu Wu
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hany SahlyErika Crouch

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