Phagocytes and C4 in paraproteinaemia.

British Journal of Haematology
L E SpitlerH H Fudenberg

Abstract

Immunological studies were performed on patients with multiple myeloma. A defect in polymorphonuclear leucocyte (PMN) function as evidenced by diminished adherence of these cells to nylon fibre columns was detected in 16, and low levels of the fourth component of complement (C4) were observed in 14, of the 26 patients studied. Twelve of the patients with low C4 exhibited the defect in PMN adhesiveness whereas only four of the 12 patients with normal C4 showed the defect. The PMN defect was not caused solely by the low C4, since PMNs from seven patients with hereditary angioedema, which is associated with low levels of C4, did not show the defect. The low C4 and defect in PMN adhesiveness occurred primarily in patients with IgG myeloma; all but one of the patients with IgA myeloma, macroglobulinaemia, or light chain disease were normal in both parameters. Results of skin window studies indicated that patients with the PMN defect also had a defect in the early PMN inflammatory response. The defect in PMN adhesiveness could be completely corrected by incubating the cells in normal plasma. Binding of the C4 to paraprotein could not be demonstrated, and C1 activation was found to be caused only by one of 10 isolated paraproteins stu...Continue Reading

References

Oct 1, 1971·Annals of Internal Medicine·E J LewisP H Schur
Jun 1, 1966·The Journal of Clinical Investigation·M R KlempererK F Austen
Dec 21, 1967·The New England Journal of Medicine·S E SalmonA Schilling
May 2, 1968·The New England Journal of Medicine·R L Baehner, D G Nathan
Aug 29, 1968·The New England Journal of Medicine·J A Winkelstein, R H Drachman
Jan 1, 1968·Annual Review of Medicine·P H Schur, K F Austen
Jan 1, 1971·British Journal of Haematology·R PennyH M Whitsed
Nov 12, 1965·Science·W F Willoughby, M M Mayer
Sep 1, 1966·British Journal of Haematology·R Penny, D A Galton
Jan 1, 1967·The Journal of Experimental Medicine·U R Nilsson, H J Müller-Eberhard
Nov 1, 1969·The Journal of Clinical Investigation·L D PetzJ Müller-Eberhard
Jul 22, 1971·The New England Journal of Medicine·E AlpertP H Schur
May 1, 1972·Immunochemistry·J GergelyH H Fudenberg
Jan 1, 1971·Arthritis and Rheumatism·R M Lewis, Y Borel
May 1, 1971·Journal of Medicinal Chemistry·G V KaiserE M Van Heyningen
Jun 1, 1970·The Journal of Experimental Medicine·T TakahashiE A Boyse
Oct 1, 1970·The Journal of Experimental Medicine·N R Cooper, H J Müller-Eberhard
Mar 25, 1971·The New England Journal of Medicine·A Mowat, J Baum
Mar 1, 1969·The Journal of Clinical Investigation·C A AlperF S Rosen
Oct 1, 1966·The Journal of Experimental Medicine·K RotherJ R Nilsson
Mar 24, 1955·Annals of the New York Academy of Sciences·J W REBUCK, J H CROWLEY
Jun 1, 1959·American Journal of Clinical Pathology·M R PACHTERJ P TRUANT
Sep 1, 1963·The Journal of Experimental Medicine·H J MUELLER-EBERHARD, C E BIRO
May 1, 1965·The Journal of Experimental Medicine·H J MUELLER-EBERHARD, I H LEPOW
Aug 1, 1965·The Journal of Experimental Medicine·P A WARDH J MUELLER-EBERHARD
Apr 1, 1960·The Journal of Clinical Investigation·S W LIPPINCOTTW L HUGHES

❮ Previous
Next ❯

Citations

Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Oct 1, 1989·The American Journal of Medicine·J J ZurloL F Fries
Jun 1, 1977·The Journal of Clinical Investigation·T Paglieroni, M R MacKenzie
Sep 1, 1980·The American Journal of Medicine·H M LazarusH M Rodman
Feb 1, 1985·Journal of Oral Pathology·T E Van DykeR J Genco
Mar 26, 2019·Annual Review of Food Science and Technology·Andreas Håkansson
Jan 20, 2009·Physical Biology·Michael Sheinman, Yariv Kafri
Jul 14, 2012·Reports on Progress in Physics·M SheinmanR Voituriez
Jan 1, 1977·The Journal of Dermatologic Surgery and Oncology·A W KopfR S Rodriguez-sains
Dec 1, 1981·American Journal of Hematology·E H Kraut, A L Sagone
Dec 1, 1981·American Journal of Hematology·B D Cheson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.