Primitive unicellular organisms depend greatly on internalization of particulate matter for nourishment. In metazoa, this process is further developed to play a major role in mechanisms of defense. This review analyzes, mainly in mammalian systems, the various phenomena surrounding the phagocytic act. Much of the emphasis is placed on experimental work which has recently elucidated some of its features. Both the structural and functional aspects of phagocytosis are considered throughout the review, which is subdivided into an examination of chemotaxis and the various agents inducing it, the mode of recognition of particles to be phagocytized, and the mechanisms of ingestion. The last includes a discussion of the possible means whereby recognition is translated into ingestion, the modes of adhesion of particles onto the surface of phagocytes, the formation and fusion of pseudopodia during engulfment and ingestion, and process and significance of degranulation. In addition, the metabolic changes in phagocytes during the processes of chemotaxis, ingestion, and digestion are described. A discussion of the various ways phagocytes may destroy microorganisms incorporates an appreciation of the importance of the microbicidal action of ...Continue Reading
The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.
The role of superoxide anion and hydrogen peroxide in phagocytosis-associated oxidative metabolic reactions.
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.
Cyproheptadine and beta cell function in the rat: insulin secretion from pancreas segments in vitro.
The requirement for membrane sialic acid in the stimulation of superoxide production during phagocytosis by human polymorphonuclear leukocytes.
Cationic proteins from human neutrophil granulocytes. Evidence for their chymotrypsin-like properties
Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease
Degranulation of chicken heterophil leucocytes during phagocytosis, studied by phase contrast and interference microscopy
Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis.
2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect
Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis
Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxis
Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes
Characterization of the macrophage receptro for complement and demonstration of its functional independence from the receptor for the Fc portion of immunoglobulin G
H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors
Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation
The mechanism of action of the C3b inactivator (conglutinogen-activating factor) on its naturally occurring substrate, the major fragment of the third component of complement (C3b).
Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane
The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils
The production by antigen-stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor
The relationship between phagocytosis of polystyrene latex particles by polymorphonuclear leucocytes (PML) and aggregation of PML
Temporal changes in pH within the phagocytic vacuole of the polymorphonuclear neutrophilic leukocyte
Cobalt as a mitochondrial density marker in a study of cytoplasmic exchange during mating of Schizophyllum commune
Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.
Specialization of the macrophage plasma membrane at sites of interaction with opsonized erythrocytes
Mouse spleen cells are sensitized sheep red blood cells: an Fc-rosette-forming system allowing the detection of "activated" Fc structures
Response of the resident macrophage to concanavalin A. Alterations of surface morphology and anionic site distribution
Toxicity of organotin compounds for polymorphonuclear leukocytes: the effect on phagocytosis and exocytosis
The inflammatory macrophage--concanavalin A interaction: a thin-section and scanning electron microscopy and laser Doppler electrophoretic investigation of surface events
Degradation of acetalated dextran can be broadly tuned based on cyclic acetal coverage and molecular weight
Pulmonary intravascular macrophages in domestic animal species: review of structural and functional properties
Cationic polyelectrolytes: a new look at their possible roles as opsonins, as stimulators of respiratory burst in leukocytes, in bacteriolysis, and as modulators of immune-complex diseases (a review hypothesis)
Polyethylenimine based magnetic iron-oxide vector: the effect of vector component assembly on cellular entry mechanism, intracellular localization, and cellular viability
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.