PMID: 9178730Jun 1, 1997Paper

Phagocytosis and burst activity of granulocytes and monocytes after stem cell transplantation

The Journal of Laboratory and Clinical Medicine
B Miyagawa, H G Klingemann

Abstract

In addition to a low number of leukocytes, an impairment of leukocyte function can also contribute to the increased susceptibility to bacterial and fungal infection in marrow transplant recipients. Phagocytosis and oxidative burst activity were measured in patients at various stages after transplant by using assay systems that are based on the quantification of the immunofluorescence of ingested bacteria. Although phagocytosis was normal in most transplant recipents, the oxidative burst of granulocytes was significantly impaired in recipients early after autologous and allogeneic transplants. Patients who underwent tests in later stages after transplant had normal leukocyte function test results. These observations are compatible with the notion that recipients early after bone marrow transplant may be able to phagocytize bacteria readily but that their ability to inactivate them via the oxidative burst might be compromised.

References

Jul 1, 1976·The Journal of Clinical Investigation·R A ClarkE D Thomas
Dec 1, 1982·The American Journal of Medicine·D J WinstonD W Golde

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Citations

Jan 25, 2007·Journal of Cancer Research and Clinical Oncology·S SchollH G Sayer
Sep 30, 2015·American Journal of Respiratory and Critical Care Medicine·Racquel Domingo-GonzalezBethany B Moore
Jun 4, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ilaria PelusoMaura Palmery
Apr 27, 2016·Pediatric Transplantation·Michael W KentRalph Quinones
Mar 31, 2010·Leukemia & Lymphoma·Charulata RamaprasadDavid L Pitrak
Jun 30, 2011·Journal of Cancer Research and Clinical Oncology·Maraike RommeleySebastian Scholl
Oct 30, 2008·Journal of Immunotoxicology·Helen G Haggerty
Nov 19, 2020·Cellular & Molecular Immunology·Cristina Tecchio, Marco Antonio Cassatella

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