Phagocytosis in cellular defense and nutrition: a food-centered approach to the evolution of macrophages

Cell and Tissue Research
V Hartenstein, P Martinez

Abstract

The uptake of macromolecules and larger energy-rich particles into the cell is known as phagocytosis. Phagocytosed material is enzymatically degraded in membrane-bound vesicles of the endosome/lysosome system (intracellular digestion). Whereas most, if not all, cells of the animal body are equipped with the molecular apparatus for phagocytosis and intracellular digestion, a few cell types are specialized for a highly efficient mode of phagocytosis. These are the ("professional") macrophages, motile cells that seek out and eliminate pathogenic invaders or damaged cells. Macrophages form the backbone of the innate immune system. Developmentally, they derive from specialized compartments within the embryonic mesoderm and early vasculature as part of the process of hematopoiesis. Intensive research has revealed in detail molecular and cellular mechanisms of phagocytosis and intracellular digestion in macrophages. In contrast, little is known about a second type of cell that is "professionally" involved in phagocytosis, namely the "enteric phagocyte." Next to secretory (zymogenic) cells, enteric phagocytes form one of the two major cell types of the intestine of most invertebrate animals. Unlike vertebrates, these invertebrates only...Continue Reading

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Citations

Sep 4, 2019·Cell and Tissue Research·V Hartenstein, P Martinez
Dec 12, 2020·Developmental Biology·Chee Kiang EweJoel H Rothman
Mar 4, 2021·Cell Reports·Jingjing WangGuoji Guo
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Cynthia Arroyo PortillaHugues Lelouard
Mar 18, 2021·Frontiers in Cellular and Infection Microbiology·Luis Johnson KangaleEric Ghigo
May 1, 2021·Nature Microbiology·Marie R JacobovitzAnnika Guse

Methods Mentioned

BETA
GTPase
electron microscopy

Related Concepts

Metazoa
Biological Evolution
Macrophage
Phagocytosis
Base Sequence
Biomaterials
Body Fluid Compartments
Digestion
Embryo
Food

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