Phagocytosis, oxidative burst, and produced reactive species are affected by iron deficiency anemia and anemia of chronic diseases in elderly

Biological Trace Element Research
Iêda Maria Martinez PainoA M de Souza

Abstract

Iron and oxidative stress have a regulatory interplay. During the oxidative burst, phagocytic cells produce free radicals such as hypochlorous acid (HOCl). Nevertheless, scarce studies evaluated the effect of either iron deficiency anemia (IDA) or anemia of chronic disease (ACD) on phagocyte function in the elderly. The aim of the present study was to determine the oxidative burst, phagocytosis, and nitric oxide (*NO) and HOCl, reactive species produced by monocytes and neutrophils in elderly with ACD or IDA. Soluble transferrin receptor, serum ferritin, and soluble transferrin receptor/log ferritin (TfR-F) index determined the iron status. The study was constituted of 39 patients aged over 60 (28 women and 11 men) recruited from the Brazilian Public Health System. Oxidative burst fluorescence intensity per neutrophil in IDA group and HOCl generation in both ACD and IDA groups were found to be lower (p < 0.05). The percentages of neutrophils and monocytes expressing phagocytosis in ACD group were found to be higher (p < 0.05). There was an overproduction of *NO from monocytes, whereas the fundamental generation of HOCl appeared to be lower. Phagocytosis, oxidative burst, and *NO and HOCl production are involved in iron metaboli...Continue Reading

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Citations

Jun 7, 2011·Brain Research·Moonhee LeePatrick L McGeer
Jun 19, 2013·Journal of Internal Medicine·A GuilhemS Dupuis-Girod
Feb 16, 2015·Environmental Toxicology and Pharmacology·Iêda Maria Martinez Paino, Valtencir Zucolotto
Oct 23, 2016·Journal of Biomedical Materials Research. Part a·Iêda Maria Martinez PainoValtencir Zucolotto
Mar 9, 2017·British Journal of Haematology·Martin N MwangiHans Verhoef
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein

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