Phagocytosis: Phenotypically Simple Yet a Mechanistically Complex Process.

International Reviews of Immunology
Vijay Kumar

Abstract

Phagocytosis is a pivotal immunological process, and its discovery by Elia Metchnikoff in 1882 was a step toward the establishment of the innate immune system as a separate branch of immunology. Elia Metchnikoff received the Nobel Prize in physiology and medicine for this discovery in 1908. Since its discovery almost 140 years before, phagocytosis remains the hot topic of research in immunology. The phagocytosis research has seen a great advancement since its first discovery. Functionally, phagocytosis is a simple immunological process required to engulf and remove pathogens, dead cells and tumor cells to maintain the immune homeostasis. However, mechanistically, it is a very complex process involving different mechanisms, induced and regulated by several pattern recognition receptors, soluble pattern recognition molecules, scavenger receptors (SRs) and opsonins. These mechanisms involve the formation of phagosomes, their maturation into phagolysosomes causing pathogen destruction or antigen synthesis to present them to major histocompatibility complex molecules for activating an adaptive immune response. Any defect in this mechanism may predispose the host to certain infections and inflammatory diseases (autoinflammatory and a...Continue Reading

References

Jul 1, 1978·The Journal of Investigative Dermatology·L M LichtensteinF J Malveaux
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Aug 1, 1969·The Journal of Allergy·S G Cohen, T M Sapp
Jan 1, 1965·Annual Review of Microbiology·J G Hirsch
Nov 1, 1995·The Journal of Experimental Medicine·B VerhovenP Williamson
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W DunneK A Joiner
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F HamadaK Toyoshima
Oct 7, 1997·The Journal of Experimental Medicine·M T CrowleyA L DeFranco
Dec 6, 1997·Nature·R E VollI Girkontaite
Dec 24, 1997·Journal of Leukocyte Biology·D E SchiffR J Ulevitch
Feb 20, 1999·The Journal of Biological Chemistry·A ShiratsuchiY Nakanishi
Jun 8, 1999·Annual Review of Immunology·A Aderem, D M Underhill
Oct 3, 1999·The Journal of Biological Chemistry·A SimonsenH Stenmark
Feb 19, 2000·Current Opinion in Immunology·C D Gregory
Feb 24, 2000·The Journal of Experimental Medicine·C J Fitzer-AttasC A Lowell
Apr 5, 2000·The Journal of Biological Chemistry·R J BotelhoS Grinstein
Jul 6, 2000·Experimental Hematology·A M Lichanska, D A Hume
Oct 12, 2000·Nature Cell Biology·G Chimini, P Chavrier
Nov 16, 2001·Seminars in Immunology·J W BoothS Grinstein
Feb 21, 2002·Molecular Biology of the Cell·Maria DiakonovaJoel A Swanson
Feb 28, 2002·Annual Review of Immunology·David M Underhill, Adrian Ozinsky
May 10, 2002·Nature·Rikinari HanayamaShigekazu Nagata
May 16, 2002·Traffic·James T MurrayJonathan M Backer
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Véronique Le CabecIsabelle Maridonneau-Parini
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·R William VandivierKelly E Greene
Dec 31, 2002·Current Opinion in Structural Biology·Thomas D Pollard, Christopher C Beltzner
Apr 12, 2003·Developmental Cell·Swathi ArurDavid K Han
Apr 18, 2003·Cell Death and Differentiation·A DevittC D Gregory
Apr 23, 2003·Archives of Biochemistry and Biophysics·Grigory G BorisenkoValerian E Kagan
Jun 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·V E KaganB Fadeel
Jun 25, 2003·The Journal of Cell Biology·Haihua GuBenjamin G Neel

❮ Previous
Next ❯

Citations

Apr 22, 2020·International Reviews of Immunology·Himanshu Kumar
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Gaël Galli, Maya Saleh
Aug 28, 2021·International Journal of Molecular Sciences·Szilvia LukácsiKrisztina Takács-Vellai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Nature Reviews. Molecular Cell Biology
A I Tauber
Journal of the Reticuloendothelial Society
L Heifets
BioMed Research International
Carlos Rosales, Eileen Uribe-Querol
Plastic and Reconstructive Surgery
Aleksandra KrajewskiRajiv Y Chandawarkar
© 2021 Meta ULC. All rights reserved