Phagocytosis promotes programmed cell death in C. elegans

Peter W ReddienH Robert Horvitz


In the nematode Caenorhabditis elegans programmed cell death requires the killer genes egl-1, ced-4 and ced-3 (refs 1 and 2), and the engulfment of dying cells requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12 (refs 3,4,5). Here we show that engulfment promotes programmed cell death. Mutations that cause partial loss of function of killer genes allow the survival of some cells that are programmed to die, and mutations in engulfment genes enhance the frequency of this cell survival. Furthermore, mutations in engulfment genes alone allow the survival and differentiation of some cells that would normally die. Engulfment genes probably act in engulfing cells to promote death, as the expression in engulfing cells of ced-1, which encodes a receptor that recognizes cell corpses, rescues the cell-killing defects of ced-1 mutants. We propose that engulfing cells act to ensure that cells triggered to undergo programmed cell death by the CED-3 caspase die rather than recover after the initial stages of death.


Mar 1, 1977·Developmental Biology·J E Sulston, H Robert Horvitz
Mar 28, 1986·Cell·H M Ellis, H Robert Horvitz
Aug 1, 1980·Developmental Biology·J E SulstonJ N Thomson
May 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·G H Little, A Flores
Nov 20, 1998·Trends in Genetics : TIG·M M MetzsteinH Robert Horvitz
Feb 13, 1999·Cell·D L Vaux, S J Korsmeyer
Mar 9, 2000·Nature Cell Biology·Peter W Reddien, H Robert Horvitz
Jul 6, 2000·Molecular Cell·Gillian M Stanfield, H Robert Horvitz


Jul 26, 2002·International Journal of Hematology·F Jon GeskeValerie A Fadok
Sep 5, 2006·Apoptosis : an International Journal on Programmed Cell Death·Dmitri V KryskoPeter Vandenabeele
Mar 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·John F FullardNicholas E Baker
Jul 25, 2009·Apoptosis : an International Journal on Programmed Cell Death·Bertrand Mollereau
Mar 20, 2010·Apoptosis : an International Journal on Programmed Cell Death·Christopher D Gregory, John D Pound
Jan 18, 2003·Biochimica Et Biophysica Acta·Patrick Williamson, Robert A Schlegel
Jan 4, 2008·Neuron Glia Biology·Mary A Logan, Marc R Freeman
Mar 2, 2012·Neuron Glia Biology·José Luis Marín-TevaJulio Navascués
Jul 12, 2002·Nature·Giovanna Chimini
Jan 14, 2012·Cell Death and Differentiation·X LiH M Chamberlin
Dec 21, 2010·Nature Cell Biology·Lukas Jakob NeukommM O Hengartner
Jul 31, 2013·Nature Immunology·Zaida G Ramirez-OrtizTerry K Means
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Jan 11, 2008·Nature Reviews. Cancer·Eduardo Moreno
Nov 27, 2007·Nature Reviews. Immunology·Kodi S Ravichandran, Ulrike Lorenz
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Guillaume Lettre, M O Hengartner
Apr 18, 2003·Cell Death and Differentiation·C TurnerChristopher D Gregory
Jan 18, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yinghui HuangRuth A Gjerset
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Aimee W KaoCynthia Kenyon
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jonas J NeherGuy C Brown
Sep 10, 2011·The Journal of Biological Chemistry·Urte NeniskyteGuy C Brown
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
May 7, 2003·The Journal of Experimental Medicine·Thomas EnzlerGlenn Dranoff
Sep 2, 2010·The Journal of Experimental Medicine·Kodi S Ravichandran
Oct 17, 2008·Molecular Biology of the Cell·Hui XiaoChonglin Yang
Dec 3, 2010·Genes & Development·Junying Yuan, Guido Kroemer
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Peter W Reddien, H Robert Horvitz
Feb 28, 2002·Annual Review of Immunology·David M Underhill, Adrian Ozinsky
Dec 10, 2002·Annual Review of Physiology·Krishnakumar Balasubramanian, Alan J Schroit
Jul 1, 2004·Arthritis Research & Therapy·Marina Botto
Apr 11, 2008·PLoS Biology·Julia Hatzold, Barbara Conradt
Sep 27, 2013·PLoS Genetics·Meredith E JudyAimee W Kao
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan E BirdJonathan E Gale
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael FrickerGuy C Brown
Jun 10, 2005·Genetics·Ky Sha, Andrew Fire
Apr 1, 2009·Genetics and Molecular Biology·María Sol BrassescoElza Tiemi Sakamoto-Hojo
Mar 22, 2014·Nature Reviews. Neuroscience·Guy C Brown, Jonas J Neher
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bin YanChuan-Yuan Li
Dec 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter W FaberAnne C Hart
Mar 19, 2014·Cell Death and Differentiation·Lukas Jakob NeukommM O Hengartner
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zsuzsa SzondyLaszlo Fesus
Oct 25, 2014·Cell Research·Qiang SunMichael Overholtzer
Dec 24, 2013·Genes & Development·Ozge E Tasdemir-Yilmaz, Marc R Freeman
Jun 11, 2004·Médecine sciences : M/S·Giovanna Chimini
Feb 22, 2012·The Journal of Cell Biology·Anat Florentin, Eli Arama
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Allison K TimmonsKimberly McCall
Aug 18, 2004·Immunology·Christopher D Gregory, Andrew Devitt
Jun 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C GuoJ W Wiley
May 20, 2003·Immunological Reviews·Saquib Lakhani, Richard A Flavell
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X-D ShenJ W Kupiec-Weglinski
Feb 13, 2016·Cell Death and Differentiation·E J Lambie, Barbara Conradt
Nov 30, 2005·Journal of Internal Medicine·B Fadeel, S Orrenius
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Xiaochen Wang, Chonglin Yang
Jul 22, 2011·Small GTPases·Lukas Jakob Neukomm, Jason Michael Kinchen
Jun 28, 2011·Cell Adhesion & Migration·Christopher D GregoryJorine J L P Willems
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brendan D GalvinH Robert Horvitz
May 14, 2016·Cell Death and Differentiation·M Eroglu, W B Derry
Jun 14, 2016·Cell Death and Differentiation·W B Derry
Oct 26, 2010·Current Biology : CB·Aimee Jaramillo-LambertJoAnne Engebrecht
Feb 22, 2005·Current Opinion in Neurobiology·Michel MallatCyril Chéret
Jan 3, 2006·Current Opinion in Neurobiology·Marc R Freeman
Nov 4, 2016·Apoptosis : an International Journal on Programmed Cell Death·Irina MilisavSamo Ribarič
Dec 22, 2016·International Journal of Molecular Sciences·Yuhei KawamotoErina Kuranaga
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
May 6, 2004·Molecular Cell·Kirsten LauberSebastian Wesselborg
Feb 26, 2004·Neuron·José Luis Marín-TevaMichel Mallat
Jun 16, 2004·Neuroscience Letters·Om P Mishra, Maria Delivoria-Papadopoulos
Sep 24, 2014·Brain Research Bulletin·Peng SuWenjing Luo
Feb 2, 2017·Progress in Neurobiology·Coralie-Anne MosserEtienne Audinat
Jun 26, 2002·Carcinogenesis·Alysson R MuotriCarlos F M Menck
Nov 20, 2003·Nature Reviews. Molecular Cell Biology·Alfred I Tauber
Dec 3, 2003·Cell Death and Differentiation·J C Ameisen
Oct 27, 2017·BMC Biology·Gongping Sun, Denise J Montell
Jul 11, 2002·Cell Death and Differentiation·B L SchwabP Nicotera
Dec 15, 2017·Frontiers in Immunology·Sandy B Serizier, Kimberly McCall
Jul 13, 2001·Nature·Douglas R Green, H M Beere
Mar 26, 2003·Cell Death and Differentiation·S NagataH Fukuyama
Jul 20, 2018·PLoS Genetics·Stephan A RaidersJames R Priess
Feb 13, 2002·The Journal of Biological Chemistry·Soren KahnsPoul Henning Jensen
Sep 13, 2015·Protein & Cell·Anna GortatMar Orzáez
Dec 7, 2018·The FEBS Journal·Yi-Nan GongDouglas R Green
Sep 23, 2003·Cell Death and Differentiation·U A Hirt, M Leist
Jan 4, 2018·G3 : Genes - Genomes - Genetics·Clarissa S SantosoKimberly McCall
Sep 11, 2004·Cell Death and Differentiation·J M Schwab, H J Schluesener
Dec 18, 2004·Cell Death and Differentiation·Björn SchumacherShai Shaham
Jun 4, 2002·Nature Cell Biology·Barbara Conradt
Nov 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alberto Chiarugi
Jan 8, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara CorbettaIvan de Curtis
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Shefali Krishna, Michael Overholtzer
Aug 16, 2016·Genetics·Barbara ConradtDing Xue
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B FadeelShazib Pervaiz
Sep 25, 2019·Cold Spring Harbor Perspectives in Biology·Carla V Rothlin, Sourav Ghosh
Apr 20, 2002·Cell Death and Differentiation·J D RobertsonS Orrenius
Apr 26, 2002·Cell Death and Differentiation·M L Coleman, M F Olson
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kaitlin DriscollH Robert Horvitz
Oct 14, 2017·Immunological Reviews·Lidia BosurgiSourav Ghosh
Jun 20, 2018·Cell Death & Disease·Isabelle MartinsJean-Luc Perfettini
Jul 28, 2020·Development·Piya Ghose, Shai Shaham
Mar 2, 2002·Traffic·Hanna Fares, Barth Grant
Oct 1, 2016·Fly·Allison K TimmonsKimberly McCall
Oct 30, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Beatriz Sáenz-NarcisoJuan Cabello
Oct 15, 2018·Cellular and Molecular Life Sciences : CMLS·Rochelle Tixeira, Ivan K H Poon
Jan 19, 2006·Biochemistry. Biokhimii︠a︡·S Ya ProskuryakovA I Kolesnikova
Sep 29, 2018·Cell Death & Disease·Rikke Hindsgaul HardersAnders Olsen
Mar 7, 2019·Royal Society Open Science·Ho Man Tang, Ho Lam Tang
Apr 26, 2019·Nature Reviews. Immunology·Greg Lemke
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kahori KurosakaYoshiro Kobayashi
Mar 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonas J NeherGuy C Brown
Jan 29, 2021·Cellular and Molecular Life Sciences : CMLS·Yuki Fujita, Toshihide Yamashita
Nov 15, 2020·Nature Reviews. Immunology·Carla V RothlinSourav Ghosh
Feb 4, 2021·Neuronal Signaling·Yuki Fujita, Toshihide Yamashita

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