Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages

British Journal of Pharmacology
U BretzJ Schnyder

Abstract

1 A slow-reacting substance (SRS) was released from non-elicited mouse peritoneal macrophages during phagocytosis of zymosan particles, whereas no detectable SRS was produced by resting cells. 2 The macrophage SRS induced a delayed and slow contraction of the guinea-pig ileum but not of the chick rectum. 3 The myotonic activity was antagonized by low concentrations of FPL 55712 (sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1 -benzopyran-2 carboxylate) but was not affected by mepyramine or hyoscine, and was not associated with tachyphylaxis. 4 SRS release was increased by indomethacin and was abolished by the lipoxygenase and cyclooxygenase inhibitor, BW755C (3-amino-1-[m-(trifluoromethyl)-phenyl]-2-pyrazoline). 5 Addition of exogenous arachidonic acid or cysteine enhanced SRS production.

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Dec 1, 1981·Agents and Actions·H P HumphrayI F Skidmore
May 1, 1986·Veterinary Research Communications·P A HenricksF P Nijkamp
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Sep 30, 1981·Biochemical and Biophysical Research Communications·B A JakschikH Sprecher

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