PMID: 9554828Apr 29, 1998Paper

Phagomimetic action of antimicrobial agents

Free Radical Research
J M GutteridgeP Kovacic

Abstract

A wide variety of extracted and synthesised drug molecules have electron transfer capabilities which allow them to generate reactive oxygen species (ROS). In particular, many antibiotics that kill or inhibit bacteria, yeasts and cancer cells readily transfer electrons to oxygen making superoxide and hydrogen peroxide in the process. When suitable redox active forms of iron are available, Fenton chemistry occurs generating the highly damaging hydroxyl radical. This type of chemistry is very similar to that which evolved within phagocytic cells as part of their microbial killing armoury. Many antibiotics, when used in model systems, have well defined pharmacological actions against key cellular functions, but their clinical usefulness is also often demonstrable at concentrations in vivo well below their in vitro minimum inhibitory concentrations. These observations have led us to propose that a common mechanism exists whereby phagocytic cells and antibiotics exploit the use of ROS for microbial killing.

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N R BachurH Kon
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TakeshitaH Ohtsubo
Mar 1, 1979·The Journal of Antimicrobial Chemotherapy·F A AndrewsW H Beggs
Jan 1, 1991·Free Radical Biology & Medicine·J M Gutteridge
Jan 1, 1990·Chemico-biological Interactions·D H PeteringW E Antholine
Aug 31, 1990·Biochemical and Biophysical Research Communications·E C ChenW E Wentworth
Sep 27, 1991·Biochemical Pharmacology·G J Quinlan, J M Gutteridge
Nov 1, 1991·The Journal of Nutrition·S E KaysM A Johnson
Jan 1, 1989·Free Radical Research Communications·G J Quinlan, J M Gutteridge
Oct 1, 1989·The Journal of Antibiotics·J H ShojiT Yoshida
Jan 1, 1989·Free Radical Research Communications·P KovacicM D Ryan
Nov 1, 1987·Biochemical Pharmacology·G J Quinlan, J M Gutteridge
May 1, 1986·Chemico-biological Interactions·K ReszkaR Docampo
Jan 1, 1988·Free Radical Research Communications·G J Quinlan, J M Gutteridge
Feb 1, 1988·Journal of Medicinal Chemistry·W J EhlhardtP Goldman
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·J R AmesP Kovacic
Jan 1, 1985·Molecular Aspects of Medicine·B Halliwell, J M Gutteridge
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·D Greenwood
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·J BrajtburgG Medoff
Apr 1, 1985·Journal of Pharmaceutical Sciences·M D RyanP Kovacic
Mar 1, 1981·Hearing Research·M G Pierson, A R Møller
Oct 1, 1980·Biochemical Medicine·J M Gutteridge, A H Thomas
Oct 20, 1995·Archives of Biochemistry and Biophysics·L K FolkesP Wardman

❮ Previous
Next ❯

Citations

Mar 15, 2005·Biochemical Pharmacology·Ruili HuangDavid G Covell
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·J M Matés, F M Sánchez-Jiménez
Feb 23, 2010·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Marilyn E Hall
Feb 23, 2010·Biochemical and Biophysical Research Communications·John M C Gutteridge, Barry Halliwell
Sep 7, 2007·Cell·Michael A KohanskiJames J Collins
Jul 18, 2008·FEMS Immunology and Medical Microbiology·Raj K UpretiAditya Pant
May 24, 2014·Journal of Applied Toxicology : JAT·Peter Kovacic, Ratnasamy Somanathan
Jun 13, 2020·Biological Trace Element Research·Subhasmita Swain, Tapash R Rautray
Nov 11, 2019·Biochemical and Biophysical Research Communications·John M C GutteridgePeter Kovacic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.