Bacteriophage genomes have mosaic architectures and are replete with small open reading frames of unknown function, presenting challenges in their annotation, comparative analysis, and representation. We describe here a bioinformatic tool, Phamerator, that assorts protein-coding genes into phamilies of related sequences using pairwise comparisons to generate a database of gene relationships. This database is used to generate genome maps of multiple phages that incorporate nucleotide and amino acid sequence relationships, as well as genes containing conserved domains. Phamerator also generates phamily circle representations of gene phamilies, facilitating analysis of the different evolutionary histories of individual genes that migrate through phage populations by horizontal genetic exchange. Phamerator represents a useful tool for comparative genomic analysis and comparative representations of bacteriophage genomes.
A component of the side tail fiber of Escherichia coli bacteriophage lambda can functionally replace the receptor-recognizing part of a long tail fiber protein of the unrelated bacteriophage T4
The C-terminal portion of the tail fiber protein of bacteriophage lambda is responsible for binding to LamB, its receptor at the surface of Escherichia coli K-12.
Genomic sequences of bacteriophages HK97 and HK022: pervasive genetic mosaicism in the lambdoid bacteriophages
Role of phages in the pathogenesis of Burkholderia, or 'Where are the toxin genes in Burkholderia phages?'
Comparative genomic analysis of 60 Mycobacteriophage genomes: genome clustering, gene acquisition, and gene size
Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments
Evolution of mosaically related tailed bacteriophage genomes seen through the lens of phage P22 virion assembly
Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates
Analysis of novel mycobacteriophages indicates the existence of different strategies for phage inheritance in mycobacteria
Characterization of Paenibacillus larvae bacteriophages and their genomic relationships to firmicute bacteriophages
Genomic characterization and comparison of seven Myoviridae bacteriophage infecting Bacillus thuringiensis
Adding pieces to the puzzle: New insights into bacteriophage diversity from integrated research-education programs
Understanding the enormous diversity of bacteriophages: the tailed phages that infect the bacterial family Enterobacteriaceae
Functional requirements for bacteriophage growth: gene essentiality and expression in mycobacteriophage Giles
Mycobacteriophage-repressor-mediated immunity as a selectable genetic marker: Adephagia and BPs repressor selection
Putative type 1 thymidylate synthase and dihydrofolate reductase as signature genes of a novel Bastille-like group of phages in the subfamily Spounavirinae
Correction: genomic comparison of 93 Bacillus phages reveals 12 clusters, 14 singletons and remarkable diversity
Genome Sequences of Mycobacteriophages AlanGrant, Baee, Corofin, OrangeOswald, and Vincenzo, New Members of Cluster B
Integration-dependent bacteriophage immunity provides insights into the evolution of genetic switches
Genomics and proteomics of mycobacteriophage patience, an accidental tourist in the Mycobacterium neighborhood
Transcriptomic Characterization of an Infection of Mycobacterium smegmatis by the Cluster A4 Mycobacteriophage Kampy
Characterization of mycobacteria and mycobacteriophages isolated from compost at the São Paulo Zoo Park Foundation in Brazil and creation of the new mycobacteriophage Cluster U
Contributions of P2- and P22-like prophages to understanding the enormous diversity and abundance of tailed bacteriophages
Function, expression, specificity, diversity and incompatibility of actinobacteriophage parABS systems
Bacteriophage: Phage Therapy
Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.