Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms

Medical Physics
Qi SunTil Aach


Recently, image-based computational fluid dynamics (CFD) simulation has been applied to investigate the hemodynamics inside human cerebral aneurysms. The knowledge of the computed three-dimensional flow fields is used for clinical risk assessment and treatment decision making. However, the reliability of the application specific CFD results has not been thoroughly validated yet. In this work, by exploiting a phantom aneurysm model, the authors therefore aim to prove the reliability of the CFD results obtained from simulations with sufficiently accurate input boundary conditions. To confirm the correlation between the CFD results and the reality, virtual angiograms are generated by the simulation pipeline and are quantitatively compared to the experimentally acquired angiograms. In addition, a parametric study has been carried out to systematically investigate the influence of the input parameters associated with the current measuring techniques on the flow patterns. Qualitative and quantitative evaluations demonstrate good agreement between the simulated and the real flow dynamics. Discrepancies of less than 15% are found for the relative root mean square errors of time intensity curve comparisons from each selected characteris...Continue Reading


Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·J M SerradorR L Bondar
Jul 27, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Z Gdovinová
Aug 1, 1965·The Journal of Clinical Investigation·J C GREENFIELD, G T TINDALL
Sep 15, 2005·Neurocritical Care·Jacques SedatPhilippe Paquis
Dec 15, 2005·IEEE Transactions on Medical Imaging·Matthew D FordDavid A Steinman
Dec 13, 2006·Journal of Biomechanical Engineering·Yiemeng HoiHui Meng
Dec 28, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yoshiyuki TokudaShigeru Maruyama
May 8, 2008·Physiological Measurement·J R CebralN Alperin
Dec 3, 2008·Journal of Biomechanical Engineering·Vitaliy L RayzDavid Saloner
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar

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