Phantom model of physiologic intracranial pressure and cerebrospinal fluid dynamics

IEEE Transactions on Bio-medical Engineering
Simone BottanVartan Kurtcuoglu

Abstract

We describe herein a novel life-size phantom model of the intracranial cavity and its validation. The cerebrospinal fluid (CSF) domains including ventricular, cysternal, and subarachnoid spaces were derived via magnetic resonance imaging. Brain mechanical properties and cranio-spinal compliance were set based on published data. Both bulk and pulsatile physiologic CSF flow were modeled. Model validation was carried out by comparisons of flow and pressure measurements in the phantom with published in vivo data of healthy subjects. Physiologic intracranial pressure with 10 mmHg mean and 0.4 mmHg peak pulse amplitude was recorded in the ventricles. Peak CSF flow rates of 0.2 and 2 ml/s were measured in the cerebral aqueduct and subarachnoid space, respectively. The phantom constitutes a first-of-its-kind approach to modeling physiologic intracranial dynamics in vitro. Herein, we describe the phantom design and manufacturing, definition and implementation of its operating parameters, as well as the validation of the modeled dynamics.

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Citations

May 9, 2013·Surgical Neurology International·Barry R LutzSamuel R Browd
Aug 26, 2014·IEEE Transactions on Bio-medical Engineering·Inga M ElixmannSteffen Leonhardt
Sep 26, 2012·IEEE Transactions on Bio-medical Engineering·Marianne Schmid DanersVartan Kurtcuoglu
Aug 8, 2015·Experimental Neurology·Reynold SpectorConrad E Johanson
Jul 25, 2015·IEEE Transactions on Bio-medical Engineering·Manuel GehlenMarianne Schmid Daners
Aug 8, 2015·AJNR. American Journal of Neuroradiology·G RingstadP K Eide
Jul 8, 2016·Annals of Biomedical Engineering·K TangenA A Linninger
May 2, 2019·Fluids and Barriers of the CNS·Anne BenninghausKlaus Radermacher

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