PMID: 8956323Nov 1, 1996Paper

Pharmaceutical approach to somatic gene therapy

Pharmaceutical Research
F D Ledley

Abstract

The pharmaceutical approach to somatic gene therapy is based on consideration of a gene as a chemical entity with specific physical, chemical and colloidal properties. The genes that are required for gene therapy are large molecules (> 1 x 10(6) Daltons, > 100 nm diameter) with a net negative charge that prevents diffusion through biological barriers such as an intact endothelium, the plasma membrane or the nuclear membrane. New methods for gene therapy are based on increasing knowledge of the pathways by which DNA may be internalized into cells and traffic to the nucleus, pharmaceutical experience with particulate drug delivery systems, and the ability to control gene expression with recombined genetic elements. This article reviews two themes in the development of gene therapies: first, the current approaches involving the administration of cells, viruses and plasmid DNA; second, the emerging pharmaceutical approach to gene therapy based on the pharmaceutical characteristics of DNA itself and methods for advanced drug delivery.

Citations

Nov 22, 2005·Expert Opinion on Drug Delivery·Volkmar Weissig
Nov 19, 2005·Expert Review of Medical Devices·Jae-Hyung JangLonnie D Shea
Oct 3, 2008·Biotechnology Journal·Zhijun WangLi Jin
Apr 15, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Leila KafshdoozAbolfazl Akbarzadeh
Feb 22, 2000·Journal of Drug Targeting·R I Mahato
Jun 9, 1997·FEBS Letters·T BoukhnikachviliJ Vacus
May 18, 2004·Human Gene Therapy·Shwu-Fen ChangJiahorng Liaw
Nov 22, 2005·Expert Opinion on Drug Delivery·Sérgio SimõesMaria Pedroso de Lima
Jun 3, 2006·Journal of Biomedical Materials Research. Part a·F Kurtis KasperAntonios G Mikos
Jun 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·N JesselJ-C Voegel
Dec 21, 2006·Pharmaceutical Research·Gerard G M D'SouzaVolkmar Weissig
Aug 11, 2007·Journal of Biomedical Materials Research. Part a·Hossein HosseinkhaniHisatoshi Kobayashi
Aug 6, 2009·Macromolecular Bioscience·Hyejung Mok, Tae Gwan Park
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D S Pisetsky, C F Reich
Nov 8, 2001·Journal of Drug Targeting·J M BennsS W Kim
Jun 8, 2001·The Journal of Biological Chemistry·M RuponenA Urtti
Oct 22, 2009·Biotechnology Journal·Atul PathakKailash Chand Gupta
Jul 22, 2016·Critical Reviews in Biotechnology·Florian S FruehMatthias W Laschke
Feb 11, 2015·The Journal of Gene Medicine·Timothy M MartinAngela K Pannier
Nov 5, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Taiebeh KafshdoozSang Woo Joo
Apr 13, 2000·Journal of Drug Targeting·J M Benns, S W Kim
Mar 10, 2001·Archives of Pharmacal Research·C K KimS J Lim
Jun 29, 1999·Nature Biotechnology·L D SheaD J Mooney
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Victoria ElazarMartin R Berger
May 1, 2010·Drug Delivery·Victoria ElazarGershon Golomb
Nov 21, 2007·Biomacromolecules·M Carmen MoránBjörn Lindman
Aug 23, 2008·Bioconjugate Chemistry·Tessa LühmannHeike Hall
May 10, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·M Carmen MoranBjörn Lindman
Oct 6, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·S HanS W Kim
Feb 19, 1999·Biochimica Et Biophysica Acta·D Y KwohD J Carlo
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·W L HinrichsW E Hennink

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