Pharmaceutical characterization of solid and dispersed carbon nanotubes as nanoexcipients.

International Journal of Nanomedicine
Marina V IvanovaMarianna Foldvari

Abstract

Carbon nanotubes (CNTs) are novel materials with considerable potential in many areas related to nanomedicine. However, a major limitation in the development of CNT-based therapeutic nanomaterials is a lack of reliable and reproducible data describing their chemical and structural composition. Knowledge of properties including purity, structural quality, dispersion state, and concentration are essential before CNTs see widespread use in in vitro and in vivo experiments. In this work, we describe the characterization of several commercially available and two in-house-produced CNT samples and discuss the physicochemical profiles that will support their use in nanomedicine. Eighteen single-walled and multi-walled CNT raw materials were characterized using established analytical techniques. Solid CNT powders were analyzed for purity and structural quality using thermogravimetric analysis and Raman spectroscopy. Extinction coefficients for each CNT sample were determined by ultraviolet-visible near infrared absorption spectroscopy. Standard curves for each CNT sample were generated in the 0-5 μg/mL concentration range for dispersions prepared in 1,2-dichlorobenzene. Raman spectroscopy and thermogravimetric analysis results demonstra...Continue Reading

References

Dec 2, 2004·Journal of Nanoscience and Nanotechnology·A C DillonM S Dresselhaus
Jun 17, 2006·Pharmaceutical Research·Patrick Couvreur, Christine Vauthier
Nov 23, 2006·Advanced Drug Delivery Reviews·Lara LacerdaKostas Kostarelos
Apr 25, 2007·Journal of Nanoscience and Nanotechnology·W WeiR J Narayan
Jun 14, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Marianna Foldvari, Mukasa Bagonluri
Jun 14, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Marianna Foldvari, Mukasa Bagonluri
Oct 14, 2008·Journal of Colloid and Interface Science·Richa RastogiLalit M Bharadwaj
Jan 2, 2010·ACS Nano·Padmaparna ChaudhuriShiladitya Sengupta
Feb 5, 2011·Current Drug Delivery·Raj Bawa

❮ Previous
Next ❯

Citations

May 8, 2014·Food Science & Nutrition·Gholamreza KavoosiMehrdad Niakosari
Oct 8, 2020·Environmental Science and Pollution Research International·Nur Jannah IdrisTetsuo Soga
Aug 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Michael A CantwellGeyou Ao

❮ Previous
Next ❯

Methods Mentioned

BETA
scraping
infrared absorption spectroscopy
transmission electron microscopy
infrared absorbance spectroscopy
X-ray

Software Mentioned

OPUS
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.