PMID: 22577957May 15, 2012Paper

Pharmaceutical cocrystals: a novel approach for oral bioavailability enhancement of drugs

Critical Reviews in Therapeutic Drug Carrier Systems
Renu ChadhaSwati Bhandari

Abstract

Solid dosage forms are by far the preferred drug delivery systems. However, these often face the problem of poor and erratic bioavailability during the drug development process. Numerous formulation strategies for drug delivery are currently under development, among which the solid forms such as polymorphs, solvates, salts, and cocrystals have been considered to be the most important for improving dissolution rate and bioavailability. Cocrystallization is a fairly new approach in pharmaceutical industry that can improve the solubility and, consequently, the bioactivity of the active pharmaceutical ingredient (API) without compromising its structural integrity. Pharmaceutical cocrystals have found their place in drug delivery, primarily due to their ability to produce alternative, viable solid forms when a more standard approach of salt and polymorph formation fails to deliver the desired objectives. Over the past few years, a number of papers have been published focusing on a broad range of subjects, from traditional crystal engineering to structure-property relationships of cocrystals. The present review, however, illustrates how the cocrystalline forms of APIs have improved their in vitro dissolution rate and in vivo bioavail...Continue Reading

Citations

Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Amol S SheteSrinivasa M Murthy
Feb 3, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jianhui LiZongwu Deng
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Bianca King LondonRao M Uppu
May 2, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dolores R SerranoAnne Marie Healy
Sep 27, 2015·The Journal of Pharmacy and Pharmacology·Dolores R SerranoAnne Marie Healy
Dec 4, 2013·Journal of Agricultural and Food Chemistry·Urszula LewandowskaSylwia Gorlach
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona BudziakDaniel M Kamiński
Jul 9, 2020·Parasitology Research·J O AdebayoS O Malomo
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roman P TerekhovTatyana G Kabluchko
Sep 2, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tatyana V Volkova, German L Perlovich

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