Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold

ACS Nano
Xinglong YangXingyu Jiang

Abstract

Remedying a multidrug-resistant (MDR) bacteria wound infection is a major challenge due to the inability of conventional antibiotics to treat such infections against MDR bacteria. Thus, developing wound dressings for wound care, particularly against MDR bacteria, is in huge demand. Here, we present a strategy in designing wound dressings: we use a small molecule (6-aminopenicillanic acid, APA)-coated gold nanoparticles (AuNPs) to inhibit MDR bacteria. We dope the AuNPs into electrospun fibers of poly(ε-caprolactone) (PCL)/gelatin to yield materials that guard against wound infection by MDR bacteria. We systematically evaluate the bactericidal activity of the AuNPs and wound-healing capability via the electrospun scaffold. APA-modified AuNPs (Au_APA) exhibit remarkable antibacterial activity even when confronted with MDR bacteria. Meanwhile, Au_APA has outstanding biocompatibility. Moreover, an in vivo bacteria-infected wound-healing experiment indicates that it has a striking ability to remedy a MDR bacteria wound infection. This wound scaffold can assist the wound care for bacterial infections.

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Citations

Mar 28, 2018·Advanced Healthcare Materials·Peiyan YuanQing-Hua Xu
Feb 10, 2018·Angewandte Chemie·Yangzhouyun XieXingyu Jiang
Mar 20, 2018·Journal of Nanobiotechnology·Menglong LiuJun Deng
Aug 19, 2017·Nanoscale·Yao-Wen JiangFu-Gen Wu
Oct 23, 2018·Advanced Materials·Ruihua DongXingyu Jiang
May 17, 2019·Biomaterials Science·Susheel Kumar NethiSudip Mukherjee
Mar 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zengchao GuoXuemei Wang
Feb 27, 2020·International Journal of Dental Hygiene·Pavithra DurgeshDurgesh H Bangalore
Jun 21, 2018·Advanced Healthcare Materials·Juanjuan LiXingyu Jiang
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Aug 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiajie LinYulin Li
Aug 19, 2020·Chemical Communications : Chem Comm·Xiaohui ZhaoXingyu Jiang
Oct 30, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xize GaoJun Wu
May 10, 2020·Scientific Reports·Poorya Chavoshnejad, Mir Jalil Razavi
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Peng WangQing Jiang
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Oct 6, 2020·Advanced Healthcare Materials·Xuecheng HeXueji Zhang
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Jun 11, 2020·Molecular Pharmaceutics·Shahriar SharifiMorteza Mahmoudi
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Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Feb 17, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fei LiJunqiu Liu

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