PMID: 17667Apr 1, 1977

Pharmaceutical suspensions: relation between zeta potential, sedimentation volume and suspension stability

The Journal of Pharmacy and Pharmacology
J B Kayes

Abstract

The effect of added surface-active agents of various ionic types on the sedimentation volume of drug suspensions of betamethasone, griseofulvin, nalidixic acid and thiabendazole has been investigated, and the results correlated with previously measured zeta potentials. Study of the zeta potential/sedimentation volumes versus concentration plots showed that apparently only coagulated, deflocculated or sterically stabilized systems were formed. In most cases the sterically stabilized systems were produced from mixtures of ionic/non-ionic surfactants. These are examples of controlled coagulation, although non-ionic surfactant alone conferred stability against caking. Secondary minimum flocculation was not apparent but this may have been due to the method of examination of suspensions. The work confirmed that the DLVO theory of colloid stability and its modification to include a steric term can be applied to coarse suspension systems.

References

Dec 1, 1968·The Journal of Pharmacy and Pharmacology·B A Matthews, C T Rhodes
Mar 1, 1971·The Journal of Pharmacy and Pharmacology·A T Florence, J A Rogers
Apr 1, 1970·Journal of Pharmaceutical Sciences·R D JonesC T Rhodes
Apr 1, 1970·Journal of Pharmaceutical Sciences·B A Matthews, C T Rhodes
Apr 1, 1968·Journal of Pharmaceutical Sciences·B A Matthews, C T Rhodes
Mar 1, 1968·Journal of Pharmaceutical Sciences·N F Ho, W I Higuchi
Mar 1, 1961·Journal of Pharmaceutical Sciences·B A HAINES, A N MARTIN
Sep 1, 1961·Journal of Pharmaceutical Sciences·B A HAINES, A N MARTIN
Sep 1, 1961·Journal of Pharmaceutical Sciences·B A HAINES, A N MARTIN

Citations

Sep 3, 2011·International Journal of Pharmaceutics·Khalil MitriRainer H Müller
Dec 1, 1978·The Journal of Pharmacy and Pharmacology·J B Kayes, D A Rawlins

Related Concepts

Centrifugation
Drug Formulation Process
Drug Stability
Electrochemistry
Ions
Mathematics
Tensides
Suspensions
Physicochemical Phenomena

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