Pharmaceutical Treatment for Alzheimer's Disease and Related Dementias: Utilization and Disparities.

Journal of Alzheimer's Disease : JAD
Douglas BartholdJulie Zissimopoulos

Abstract

Four prescription drugs (donepezil, galantamine, memantine, and rivastigmine) are approved by the US FDA to treat symptoms of Alzheimer's disease (AD). Even modest effectiveness could potentially reduce the population-level burden of AD and related dementias (ADRD), especially for women and racial/ethnic minorities who have higher incidence of ADRD. Describe the prevalence of antidementia drug use and timing of initiation relative to ADRD diagnosis among a nationally representative group of older Americans, and if there are disparities in prevalence and timing by sex and race/ethnicity. Descriptive analyses and logistic regressions of Medicare claims (2008-2016) for beneficiaries who had an ADRD or dementia-related symptom diagnosis, or use of an FDA approved drug for AD. We investigate prevalence of use and timing of treatment initiation relative to ADRD diagnosis across time and beneficiary characteristics (age, sex, race/ethnicity, socioeconomic status, comorbidities). Among persons diagnosed with ADRD or related symptoms, 33.3% used an approved drug over the study period. Odds of use was higher among Whites than non-Whites. Among ADRD drug users, 40% initiated use within 6 months of the initial ADRD or related symptoms diag...Continue Reading

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Citations

Aug 28, 2020·Pharmacoepidemiology and Drug Safety·Douglas BartholdJulie Zissimopoulos
Mar 30, 2021·JAMA Neurology·Claudia H KawasRachel A Whitmer
Jul 13, 2021·Healthcare : the Journal of Delivery Science and Innovation·Bian LiuEmanuela Taioli
Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Maria PisuDavid S Geldmacher
Jan 11, 2022·CNS Drugs·Laiba AzharNathan Herrmann

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