Pharmaceutical treatment options for fibromyalgia

Current Rheumatology Reports
Leslie J Crofford

Abstract

Fibromyalgia syndrome (FMS) is a chronic multisymptom illness characterized by widespread pain and associated with neuropsychological symptoms including fatigue, unrefreshing sleep, cognitive dysfunction, anxiety, and depression. A discreet cause of FMS has not been identified. It is likely that multiple mechanisms give rise to symptom expression. Understanding specific etiologic factors and pathogenic mechanisms in individual patients will allow clinicians to determine treatments that are most effective for a given patient. Available evidence implicates the central nervous system as key in maintaining pain and other core symptoms of FMS. The approach to treatment of pain will typically address these central mechanisms. Nonpain symptoms may be treated by drugs affecting similar central neurochemicals. This paper will review the rationale for the different types of pharmaceutical treatments that may be useful for the treatment of FMS and issues regarding new drug development for this indication.

References

Mar 1, 1989·The American Journal of Medicine·K Kroenke, A D Mangelsdorff
Jan 1, 1984·Annual Review of Medicine·A H Glassman
Aug 1, 1981·Seminars in Arthritis and Rheumatism·M YunusS L Feigenbaum
Jan 1, 1995·Arthritis and Rheumatism·F WolfeL Hebert
Nov 1, 1994·Baillière's Clinical Rheumatology·C S Burckhardt, A Bjelle
Jan 1, 1994·Scandinavian Journal of Rheumatology·F WolfeD J Hawley
Apr 16, 1998·Psychosomatics·M M DwightP E Keck
Sep 28, 1998·JAMA : the Journal of the American Medical Association·K FukudaW C Reeves
Oct 8, 1999·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·S E GowansM Richardson
Oct 21, 1999·Neurobiology of Disease·B BondyM Ackenheil
Apr 6, 2000·Psychosomatics·L M ArnoldJ A Welge
Oct 13, 2000·Journal of General Internal Medicine·P G O'MalleyJ L Jackson
May 11, 2001·Annals of Internal Medicine·K Kroenke, L Harris
Jan 24, 2002·Neuropharmacology·Klaus FinkManfred Göthert
Nov 29, 2002·Scandinavian Journal of Rheumatology·Kaisa MannerkorpiCharlotte Ekdahl
Feb 13, 2003·Archives of General Psychiatry·James I HudsonMing T Tsuang
Feb 22, 2003·American Journal of Physical Medicine & Rehabilitation·Angela PfeifferJohn Postier
May 10, 2003·Rheumatology International·Savaş GürsoyNurten Erdal
Jul 9, 2003·Arthritis and Rheumatism·Erin L ArnoldMark P Goodman
Jul 10, 2003·Best Practice & Research. Clinical Rheumatology·Kaisa Mannerkorpi, Maura Daly Iversen
Jul 10, 2003·Best Practice & Research. Clinical Rheumatology·David A Williams
Jul 10, 2003·Best Practice & Research. Clinical Rheumatology·Daniel J Clauw, Leslie J Crofford
Oct 21, 2003·The Annals of Pharmacotherapy·Kemal SayarMehmet Tosun

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Citations

Oct 14, 2006·Rheumatology International·Elena P CalandreFernando Rico-Villademoros
Dec 15, 2010·The Journal of Pain : Official Journal of the American Pain Society·Anne Chamberlin SilerMarian McDonagh
Nov 3, 2007·Seminars in Arthritis and Rheumatism·Piercarlo Sarzi-PuttiniFabiola Atzeni
Mar 19, 2011·Journal of Clinical Pharmacology·Pinky DharmshaktuBhupinder Singh Kalra

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